Trichinellosis is a resurgent parasite that affects people globally. Acid suppressing drugs (ASDs) are among the most frequently prescribed and generally safe medications in many distinct processes (changes defense mechanisms as gut microbiota and immunology). The study evaluated the antacids effect of aluminium hydroxide and magnesium hydroxide in treating Trichinella spiralis in experimental infected mice. Mice (128) were divided into four groups GI: negative control (non-infected untreated), GII: positive control (infected untreated), GIII: mice were infected and treated with albendazole and GIV: mice were infected and treated with antacids. Half of them were sacrificed on 7 th day post infection (PI) for intestinal phase and second half were sacrificed on 35 th day PI for muscular phase. Treatment efficiency was assessed by parasitological, biochemical and histopathological examinations.The results showed that antacids treated mice gave highest number of T. spiralis adult count in intestine and larval count in muscle. Antacids increased the infection (30.5%, 32.5%) respectively compared to infected control. Biochemically showed higher level of IL4, IL10, MDA and lower level of GSH than infected control.
Toxoplasmosis is a contagious illness that is brought on by the parasite Toxoplasma gondii. The strain of Toxoplasma gondii may have an effect on how severe the symptoms of toxoplasmosis are. Immunocompromised people are more likely to develop neurological, ocular, and systemic diseases as a result of toxoplasmosis. Rosuvastatin ® is one of the promising drugs in the treatment of toxoplasmosis. This study determined the rosuvastatin efficacy in treating murine toxoplasmosis. This is being done in an effort to make up for the deficiencies that are present in other standard medications. Mice were divided into 7 groups of 10 mice each. GI: Neither infected nor treated (normal control). GII: Infected, non-treated mice (positive control). GIII: Mice given Spiramycin ® as prophylaxis before infection. GIV: Mice given rosuvastatin as prophylaxis before infection. GV: Mice infected and treated by spiramycin after 6 th week for 2 weeks. GVI: Mice infected and treated by rosuvastatin after 6 th week for 2 weeks. GVII: Following the sixth week, infection was confirmed, and treatment consisted of a combination of rosuvastatin and spiramycin for two weeks. Histological examination of brain and liver, and counting brain cysts, were used to evaluate the efficacy of treatment.The results showed that rosuvastatin treated group showed significant reduction in brain cysts and improved histopathological picture in brain and liver tissue. Combination of rosuvastatin and spiramycin gave the best results in reduction of brain cysts number and the least pathological changes in brain and liver tissue. The effect of rosuvastatin was augmented after combination with spiramycin.
Trichinellosis is a worldwide risky zoonotic nematode infecting people particularly in pig raising countries. The present study evaluated management of Trichenella spiralis infection with Kalobin ® , a widely used herbal remedy for respiratory infections as compared to Albendazole ® .Consequently, one hundred Swiss albino male mice were divided in five groups of 20 each. GI: untreated, uninfected mice (negative control). GII: infected untreated mice (positive control). GIII: infected treated with Albendazole (ABZ) started three days after infection and continued for three successive days. GIV: infected and treated with Kalobin began 24 hours after infection and went on for 6 consecutive days since infection. GV: infected mice and Kalobin treated started 15 day before infection up to 6 successive days (pretreated group). Two hundred T. spiralis larvae were given orally to all groups except GI and evaluated parasitological, histopathological, and biochemical of the efficacy of treatment.The results showed that both GIII and GV caused substantial decrease in intestinal adults' count than other ones (94.4%, & 52.1% respectively). These results were supported by the enhancement of histology and biochemistry findings.
The need for new alternative treatment for trichinosis is being motivated by the growing resistance and low bioavailability of current therapies. In this study, experimental mice were used to assess the therapeutic effects of rifampicin alone or in combination with albendazole against Trichinella spiralis. One hundred male mice were classified into five groups of 20 mice each, G1: negative or normal control (non-infected untreated), G2: positive control (infected untreated), G3: drug control (infected and albendazole treated), G4: infected and rifampicin treated, and G5: infected and treated by albendazole and rifampicin combination. Half of the mice were sacrificed on the 10 th day post infection (dpi) for the intestinal phase and the other half were sacrificed on the 40 th dpi for the muscular phase. The treatment effectiveness was evaluated by parasitological, histological, and biochemical tests in contrast with positive control. Mice given albendazole and rifampicin combination gave a highly significant decrease in T. spiralis intestinal adult count, larval count in muscle and lowered liver activity enzymes. This was documented by the histopathology of liver, muscles and intestines.
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