The problem of computer-aided classification of benign and malignant breast masses using shape features is addressed. The aim of the study is to look at the exceptions in shapes of masses such as circumscribed malignant tumours and spiculated benign masses which are difficult to classify correctly using common shape analysis methods. The proposed methods of shape analysis treat the object's boundary in terms of local details. The boundaries of masses analysed using the proposed methods were manually drawn on mammographic images by an expert radiologist (JELD). A boundary segmentation method is used to separate major portions of the boundary and to label them as concave or convex segments. To analyse the shape information localised in each segment, features are computed through an iterative procedure for polygonal modelling of the mass boundaries. Features are based on the concavity fraction of a mass boundary and the degree of narrowness of spicules as characterised by a spiculation index. Two features comprising spiculation index (SI) and fractional concavity (fcc) developed in the present study when used in combination with the global shape feature of compactness resulted in a benign/malignant classification accuracy of 82%, with an area (Az) of 0.79 under the receiver operating characteristics (ROC) curve with a database of the boundaries of 28 benign masses and 26 malignant tumours. SI alone resulted in a classification accuracy of 80% with Az of 0.82. The combination of all the three features achieved 91% accuracy of circumscribed versus spiculated classification of masses based on shape.

We propose a method for the detection of masses in mammographic images that employs Gaussian smoothing and sub-sampling operations as preprocessing steps. The mass portions are segmented by establishing intensity links from the central portions of masses into the surrounding areas. We introduce methods for analyzing oriented flow-like textural information in mammograms. Features based on flow orientation in adaptive ribbons of pixels across the margins of masses are proposed to classify the regions detected as true mass regions or false-positives (FPs). The methods yielded a mass versus normal tissue classification accuracy represented as an area (Az) of 0.87 under the receiver operating characteristics (ROCs) curve with a dataset of 56 images including 30 benign disease, 13 malignant disease, and 13 normal cases selected from the mini Mammographic Image Analysis Society database. A sensitivity of 81% was achieved at 2.2 FPs/image. Malignant tumor versus normal tissue classification resulted in a higher Az value of 0.9 under the ROC curve using only the 13 malignant and 13 normal cases with a sensitivity of 85% at 2.45 FPs/image. The mass detection algorithm could detect all the 13 malignant tumors successfully, but achieved a success rate of only 63% (19/30) in detecting the benign masses. The mass regions that were successfully segmented were further classified as benign or malignant disease by computing five texture features based on gray-level co-occurrence matrices (GCMs) and using the features in a logistic regression method. The features were computed using adaptive ribbons of pixels across the boundaries of the masses. Benign versus malignant classification using the GCM-based texture features resulted in Az = 0.79 with 19 benign and 13 malignant cases.

Computer-aided classification of benign and malignant masses on mammograms is attempted in this study by computing gradient-based and texture-based features. Features computed based on gray-level co-occurrence matrices (GCMs) are used to evaluate the effectiveness of textural information possessed by mass regions in comparison with the textural information present in mass margins. A method involving polygonal modeling of boundaries is proposed for the extraction of a ribbon of pixels across mass margins. Two gradient-based features are developed to estimate the sharpness of mass boundaries in the ribbons of pixels extracted from their margins. A total of 54 images (28 benign and 26 malignant) containing 39 images from the Mammographic Image Analysis Society (MIAS) database and 15 images from a local database are analyzed. The best benign versus malignant classification of 82.1%, with an area (Az) of 0.85 under the receiver operating characteristics (ROC) curve, was obtained with the images from the MIAS database by using GCM-based texture features computed from mass margins. The classification method used is based on posterior probabilities computed from Mahalanobis distances. The corresponding accuracy using jack-knife classification was observed to be 74.4%, with Az = 0.67. Gradient-based features achieved Az = 0.6 on the MIAS database and Az = 0.76 on the combined database. The corresponding values obtained using jack-knife classification were observed to be 0.52 and 0.73 for the MIAS and combined databases, respectively.

The problem of computer-aidcd classification of benign and ~nalignant breast masses as seen on maminograms iisiiig morphological features is addressed in this paper. We propose methods of shape analysis treating the ob.ject's boundary in terms oflocal details. We use an iterative boundary segmentation method to separ a k ma.jor portions of the boundary and label them as concave or convex segments. In order to analyze the shape information localized in each segment, we comput? features Irhrough polygonal modeling of the tutiior boundaries. The features developed in the present st.iidy wlieii used in combination with the global shape feature of compactness resulted in a classification accuracy of 81% with a database of 28 benign masses and 25 malignant tumors.