Anti- phospholipid syndrome (APS) is an autoimmune prothrombotic disease characterized by persistently elevated antiphospholipid antibodies, resulting in recurrent arterial and venous thromboembolic events. The deep veins of the lower limbs and the cerebral arterial circulation are the most common sites of venous and arterial thrombosis, respectively [1] The other major clinical manifestations of the antiphospholipid syndrome are obstetrical. They include the unexplained death of one or more morphologically normal fetuses at or beyond the 10th week of gestation, the premature birth of one or more morphologically normal neonates before the 34th week of gestation because of either eclampsia or severe preeclampsia, and three or more unexplained, consecutive spontaneous abortions before the 10th week of gestation [2] Thrombotic events post COVID 19 infection has been described since the beginning of pandemic in 2019[3]. Autopsy reports have shown that most thromboses are located in the lung, although they have also been observed in other organs such as the skin and kidneys. SARS-CoV2 infection induces a generalized prothrombotic state, which is attributed to a combination of factors such as hypoxia, excess cellular apoptosis, and mainly to overactivation of the immune system [4]. Considering the high rate of mortality due to coagulation abnormalities and thrombosis among coronavirus disease 2019 patients, it is important to pay attention to the differential diagnoses of coronavirus disease 2019 and other diseases following thrombotic events [5].
Ovarian vein thrombosis (OVT) is a rare condition occurring in 1/600 to 1/2000 pregnancies mainly in the postpartum setting[1,2]. However,it is a potentially life-threatening condition andcan occur in other circumstances, such as inflammatory diseases of the pelvis, gynecological tumors, after pelvic surgery, during sepsis, hypercoagulable state, or even sometimes without an underlying cause [2]. It is usually manifested by nonspecific abdominal pain, with or without fever, and must be recognized because of its potentially serious complications (pulmonary embolism) [2,5]. Currently, the diagnosis is done earlier thanks to imaging techniques making the prognosis better[3,4].
Coronavirus disease-2019 (COVID-19) is a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The outcomes and severity of COVID-19 are dependent on comorbidities such as diabetes mellitus, cardiovascular diseases including hypertension, kidney disease, pulmonary disease, and age[1,2,3]Since December 2019, the whole world suffers from (SARS-CoV-2) that was declared by the World Health Organization (WHO) as a global pandemic on March 11, 2020[4]Liver transplant (LT) recipients, being immunosuppressed, are prone to severe infections [5]. Therefore, the presence of comorbidities and chronic immunosuppression may increase the risk of severe COVID-19 among liver transplant recipients [6],[7].
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