The experiment was conducted at Poultry Research center University of Agriculture Faisalabad to evaluate the Arsilvon super, Bedgen40 and Hepa-Cure herbal medicines on broiler performance, immunity and hematology. For this study one hundred eighty day old broiler chicks were purchased from local hatchery and were reared in a group for one week. After one week, one hundred twenty broiler chicks of middle weight range were picked up randomly and divided into 12 experimental units (10 chicks/each).These units were allotted to 4 groups A, B, C, and D such that A group served as control without any supplementation, group B was supplemented with Arsilvon super @1ml/L, group C was supplemented with Bedgen40 @ 0.5ml/4L, and D was supplemented with Hepa-cure @ 1ml/L in drinking water. Supplementation of herbal medicine exhibited significant (P<0.05) effects on weight gain, Feed Conversion Ratio and non-significant effect on feed consumption (P> 0.05). Supplementation of herbal medicines showed significant treatment effect against the Newcastle disease but non-significant effect against the Infectious bursal disease. Herbal medicines revealed significant effects on blood glucose and red blood cells, but showed non-significant effect on cholesterol, hemoglobin, white blood cells and packed cell volume. In conclusion, herbal medicine supplementations in broiler revealed positive effect on performance, immunity and hematological parameters.
ABSTRACT… Background: Coronary artery ectasia (CAE) is well-recognized but relatively uncommon finding during diagnostic coronary angiography. Coronary artery ectasia is defined as a segment of coronary artery that is 1.5 times more dilated in diameter than the nearby segments. Its clinical presentations are unstable angina, coronary vasospasm, and acute myocardial infarction. Objectives: To determine the clinical characteristics, presentation and treatment in patients with documented coronary artery ectasia in a single Cardiac Centre at Faisalabad City Pakistan. Study Design: Retrospective descriptive study. Materials and Methods: This was a single center retrospective, descriptive study. Patients of either gender with age 21-70 years who had coronary angiography at Faisalabad Institute of Cardiology Faisalabad were included in the study. Coronary angiograms performed from April 2013 to December 2016 were reviewed. Patients fulfilling inclusion and exclusion criteria were enrolled. Clinical and angiographic profiles of the patients having coronary ectasia were retrieved from hospital record. Clinical profile included: age, gender and cardiovascular risk factors. Angiographic profile; prevalence of coronary ectasia, type of ectasia, associated obstructive disease and coronary vessel involved were noted. Results: Total 22235 patients under went coronary angiography from April 2013 to December 2016 at Faisalabad Institute of Cardiology Faisalabad. Out of 22235, 16913(76%) were male and 5322(24%) were female. Coronary artery ectasia (CAE) was observed in 1044(4.7%). Out of 1044, 931(89%) were male and 113(10.9%) were female patients. Mean age of study population was 49.5 ± 11.8 years. 368(31.97%) patients with CAE were in age group of 51-60 years followed by age group 41-50 years. 672 (64.36%) were hypertensive, 433 (41.7%) were diabetics, smoker were 574(54.98%). 442(42.33%) patients presented with ST elevation MI. 750 (71.84%) patient had mild Ectasia, 155 (34.87%) were suffering from severe coronary Ectasia. 364 (34.87%) patients had associated obstructive coronary artery disease. LAD was most commonly involved vessel in 392 (37.50%) followed by right coronary artery in 323 (30.94%). Type I ectasia was documented in 34.92%. Conclusions: In our study prevalence of CAE was 4.7%. CAE was more common in male, hypertensive, smokers and patients with Hyperlipedemia. Most common pattern of CAE was Type I and isolated ectasia without coronary artery obstruction. Left anterior descending artery was the most commonly involved vessel in ectasia followed by RCA. Key words:Ectasia, Angina, Infarction, Coronary artery.
ABSTRACT… Introduction: Atherosclerosis is intrinsically an inflammatory disease. Numerous studies has shown that elevated levels of C-reactive protein (CRP) are associated with increased cardiovascular risk. The objectives of this study was to determine the correlation of clinical outcome in terms of 30 day mortality with various level of C-reactive proteins among patients presenting with acute coronary syndrome Study Design: Descriptive. Setting: Department of Cardiology, Punjab Institute of Cardiology Lahore. Period: 06 months. Material and Methods: Total 250 patients presented in emergency department and diagnosed as cases of acute coronary syndrome base on history of chest pain, ECG and cardiac biochemical markers were included in the study. Management of ACS was continued while CRP levels of each patient were measured by latest Agglutination method. Results: Our study included 250 patients with acute coronary syndrome with a mean age of 52.90±10.34 years. Male patients were 220 (88%). Regarding the clinical presentation of patients, 20 (8%) had unstable angina, 95(38%) had NSTEMI and 135 (54%) had STEMI.CRP level were measured, 184(73.6%) patients had CRP levels < 22mg/L with mortality of 12 (6.5%) at 30 days and 66 (26.4%) patients had CRP levels >22mg/L with mortality of which 13(19.6%) at 30 days. The mean CRP level was 17.9±12.47, 18.08±15.73 and 22.38 + 17.92 for patients with unstable angina, NSTEMI and STEMI respectively. The stratification of data for effect modifiers showed that 60(24%) patients had diabetes, 138 (55.2%) patients had hypertension and 65(26%) patients were smokers. Conclusion: Patients having higher CRP levels had higher risk of 30 day mortality. Key words:C-reactive protein, Acute coronary syndrome. Article Citation: Maqbool A, Asghar N, Ahmad S. Acute coronary syndrome; Co-relation of C-reactive protein with clinical outcome of patients.
ABSTRACT… Introduction: Atrial fibrillation (AF) and wider QRS duration have long been identified to worsen heart failure and LV dysfunction and increase cardiovascular morbidity and mortality. Therefore, it is necessary to identify those patients of heart failure who are at greater risk for cardiovascular morbidity and mortality so that such subjects may be focused for preventive strategies. An association exists between QRS duration and AF with greater incidences of cardiovascular events in patients of heart failure with LV systolic dysfunction. Sampling technique was non-probability, purposive sampling. Result: The study population consisted of male (72.3%) and female (27.7%). Mean LA diameter was 40.3±6.08 mm and mean LV ejection fraction 31.8±6.6 % in the study population. Ischemic heart disease was the most common cause of LV dysfunction (88.3%) followed by non-ischemic cardiomyopathy (8.75%) and non-Ischemic valvular heart disease (3.5%). The frequency of Narrow QRSd (<120 ms) was 62%, Intermediate QRSd (120-150 ms) was 26.5% and Wide QRSd (>150 ms) was 11.5%. The frequency of atrial fibrillation in study population was 15.75%. The frequency of atrial fibrillation was highest in Wide QRSd group (>150 ms) i.e. (60.9%), followed by Intermediate QRSd group (120-150 ms) i.e. (18.9%) and narrow QRSd group (<120 ms) i.e. (6.04%). Patient with atrial fibrillation were more likely to have poor ejection fraction (P<0.0023) and wider QRS duration (P<0.0001). Frequency of atrial fibrillation was highest in Valvular Cardiomyopathy (non-ischemic valvular heart disease) patients (42.8%) as compared to coronary artery disease group (15.3%) and non-ischemic cardimyopathy group (9.4%). Conclusion: In patients of heart failure with reduced ejection fraction (HFrEF), the frequency of atrial fibrillation increases as QRS duration widens. This group of patients must be focused for AF preventive strategies. Key words:Atrial fibrillation (AF), Left ventricular (LV), QRS duration (QRSd). Article Citation: Mir N, Asghar N, Javed S. Heart failure; co-relation of QRS duration with atrial fibrillation in patients with reduced ejection fraction. Professional Med J 2017;24(6):912-918.
Introduction: Atherosclerosis is intrinsically an inflammatory disease. Numerousstudies has shown that elevated levels of C-reactive protein (CRP) are associated with increasedcardiovascular risk. The objectives of this study was to determine the correlation of clinicaloutcome in terms of 30 day mortality with various level of C-reactive proteins among patientspresenting with acute coronary syndrome Study Design: Descriptive. Setting: Department ofCardiology, Punjab Institute of Cardiology Lahore. Period: 06 months. Material and Methods:Total 250 patients presented in emergency department and diagnosed as cases of acutecoronary syndrome base on history of chest pain, ECG and cardiac biochemical markers wereincluded in the study. Management of ACS was continued while CRP levels of each patientwere measured by latest Agglutination method. Results: Our study included 250 patients withacute coronary syndrome with a mean age of 52.90±10.34 years. Male patients were 220(88%). Regarding the clinical presentation of patients, 20 (8%) had unstable angina, 95(38%)had NSTEMI and 135 (54%) had STEMI.CRP level were measured, 184(73.6%) patients hadCRP levels < 22mg/L with mortality of 12 (6.5%) at 30 days and 66 (26.4%) patients hadCRP levels >22mg/L with mortality of which 13(19.6%) at 30 days. The mean CRP level was17.9±12.47, 18.08±15.73 and 22.38 + 17.92 for patients with unstable angina, NSTEMI andSTEMI respectively. The stratification of data for effect modifiers showed that 60(24%) patientshad diabetes, 138 (55.2%) patients had hypertension and 65(26%) patients were smokers.Conclusion: Patients having higher CRP levels had higher risk of 30 day mortality.
ABSTRACT… Background: Coronary artery lesion severity is physiological assessed by fractional myocardial flow reserve (FFR) FFR assessment was done using FFR wire during maximal blood flow (hyperemia) which was induced by injecting bolus dose of intracoronary adenosine. The cost of procedure was managed by hospital. Results: In this study, 28.33% (n=17) were between 20-50 years of age, mean+SD was calculated as 55.17+8.04 years, 51.67% (n=31) were male and 48.33% (n=29) were females. Correlation between mean lesion length of diffuse intermediate stenosis (40%-70% stenosis) of proximal and mid segment of major coronary arteries and mean fractional flow reserve (FFR) was recorded it shows that mean lesion length was 24.53+4.78 mm while FFR was recorded as 0.72+0.12, the value of R is -0.1928, technically a negative correlation, the relationship between variables is only weak (the nearer the value is to zero, the weaker the relationship). The value of R 2 , the coefficient of determination, is 0.0372. Conclusion: The correlation between mean lesion length of diffuse intermediate stenosis (40%-70% stenosis) of proximal and mid segment of major coronary arteries and mean fractional flow reserve (FFR) was weak and did not suggest any hemodynamic significance of diffuse intermediate coronary artery lesions.
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