These authors contributed equally to this work.
ObjectivesTo generate real-time radio-telemetric urodynamic reference data of maximum detrusor pressure (P det max ), maximum flow rate (Q max) and estimated grade of infravesical obstruction, as well as duration of detrusor contraction (DOC), in female G€ ottingen minipigs and to describe translational aspects of the use of G€ ottingen minipigs for urological research.
Materials and MethodsA telemetric transmitter was implanted into five female G€ ottingen minipigs, and 24 h measurements in metabolic cages were taken. Through operator-based analysis, synchronized real-time radio-telemetric cystometric data with flowmetric data and video sequences were used to determine voiding detrusor contractions (VCs) and non-voiding detrusor contractions (NVCs). Furthermore, data from telemetric natural-filling cystometry from free-moving and restricted maintenance conditions were compared for potential differences.
ResultsThe median (range) P det max of VCs was 120.6 (21.0-370.0) cmH 2 O and, therefore, significantly different from that of .6 cmH 2 O] cm H 2 O). Intraindividual comparison of minipig data revealed great differences in voiding contractions. The effects of limited movement on VCs were analysed and showed significantly higher P det max and lower DOC than in free-moving conditions.
ConclusionThe presented data can be used for the development of telecystometric implanted minipig models, to investigate changes of detrusor function such as under-or overactivity, and might serve as model for bladder changes occurring with iatrogenic bladder outlet obstruction (BOO) or different therapeutic options for overactive bladder. Radio-telemetric real-time natural filling and voiding cystometries are feasible, reproducible in non-anaesthetized minipigs with free or limited movement and can give new insights into circadian behaviour and physiological and pathological bladder function.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.