A convenient preparation of 3-and 4-(1H-azol-1-yl)piperidines by arylation of azoles (i.e., pyrazoles, imidazoles, and triazoles) with 3-and 4-bromopyridines and subsequent reduction of the pyridine ring was developed. The method was extended to benzo analogues of the title compounds.
A Convenient Synthesis of (1H-Azol-1-yl)piperidines. -A convenient two-step sequence including heteroarylation of azoles and subsequent reduction allows the synthesis of various N-heterocyclic systems as potential drug candidates. -(SHEVCHUK, N. V.; LIUBCHAK, K.; NAZARENKO, K. G.; YURCHENKO, A. A.; VOLOCHNYUK, D. M.; GRYGORENKO*, O. O.; TOLMACHEV, A. A.; Synthesis 2012, 13, 2041-2048, http://dx.doi.org/10.1055/s-0031-1291126 ; Enamine Ltd., Kiev 01103, Ukraine; Eng.) -Mais 42-156
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