Various approaches have been developed for diminishing the effects of radiation on normal tissues or enhancing tumor cell killing by ionizing radiation. Recently, there has been an increase in the interest in research on synthetic and/or natural radioprotective agents. An important potential use for these agents is to modify and improve the outcome of radiation therapy. The aim of this study was to examine the potential radioprotective role and antioxidant potency of the novel synthetic anticancer agent, quinoline sulfonamide (PIQSA) against tissue injury and oxidative stress induced by the exposure to gamma radiation and/or incidence of cancer in experimental animals. Mice (normal and bearing solid tumors) administered PIQSA (0.350 mg/kg body weight ip. three times a week for 21 days. At the last week of 30 days experimental period, an animal group was subjected to three successive doses of γ-radiation each of 2 Gy; another group was treated with combined administration of PIQSA 20 minutes before γ-irradiation. Some biochemical parameters (LPx, GSH, SOD, and CAT in liver homogenates, also plasma lipid profile (total lipids, total cholesterol, total triglycerides (TG), HDLc and LDLc were measured. To examine any adverse effect which could be attained by chemical treatment, liver enzymes (AST, ALT), and kidney function (creatinine and urea) were estimated in blood plasma, in addition to examination of some haematological indexes. The results indicated that the deleterious effects due to exposure to γ-radiation, and/or incidence of cancer on most of the estimated parameters could be controlled to a certain extent by administration of PIQSA to animals prior to irradiation. The results also confirmed that there were no significant adverse effects on mice due to the treatment with this chemical compound
Context: Urinary incontinence is an important multifactorial health problem that affects women's life quality negatively and is related significantly to age, education, occupation, marital status, and body mass index.
Aim: To evaluate the effectiveness of nursing guidelines on marital outcomes of women with urinary incontinence.
Methods: Quasi-experimental (pre/posttest, study/control) design was used. The study was conducted at the urogynecology unit at Ain Shams Maternity University Hospital on a purposive sample of 76 women attending the setting mentioned above. Sample inclusion criteria were women age <40 years, married, diagnosed with urinary tract infection, and free from chronic disease. The study tool included a structured interview questionnaire, Kings’ health questionnaire, women practice checklist.
Results: Findings of the present study showed that 43.4% of the women were housewives, 27.6% completed preparatory school education. There were highly statistically significant differences between study and control groups regarding physical, social, sexual, and psychological dimensions of King's health outcomes post and followed up of guidelines implementation when the p-value was <0.001. The practice of the study group improved significantly than controls.
Conclusion: The study revealed improvement in the total health outcomes and health practice among the study group compared to the controls with an increase in the total practice with the decrease in total health problems of king health, especially sexual problems. Recommendations: Performing training programs for improving women's awareness about urinary incontinence and sexual life. Replication of the study on a larger probability sample for generalizing the findings and studying the factors affecting women's utilization of urodynamic services.
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