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Thermochromic liquid crystals (TLCs) have been widely employed by researchers in heat transfer and fluid flow communities as a reliable and non-intrusive temperature measurement tool due to their unique optical properties such as birefringence, optical activity, circular dichroism and selective reflection of colours in the visible spectrum as function of temperature. The use of narrowband TLCs are attractive for temperature and heat transfer measurements due to their higher precision in temperature measurements and due to the fact that narrowband TLCs are less affected by variations in illumination-viewing angles and illumination disturbances. Narrowband TLCs have been used with full intensity-matching methods to provide robust image processing for measurements of thermal parameters in transient heat transfer tests. Calibration of narrowband TLCs is necessary in order to obtain the intensity-temperature relationship of the TLCs. Film thickness is one of the factors which affects calibrations of TLCs. In this research, film thicknesses of 10, 20, 30, 40 and 50 μm were investigated on green intensity-based calibrations of R35C1W TLC during heating and cooling. Results showed an increase in magnitude of peak green intensity with increasing film thickness, with a percentage increase of nearly 18% when film thickness increased from 10 to 50 μm. Results also showed an inconsistent shift in temperature at which peak green intensity occurs, with a maximum shift of 0.40 °C, suggesting that film thickness effects may be insignificant for narrowband TLCs compared with wideband TLCs. A theoretical method for estimating the volume of TLC coating required to achieve a desired film thickness has also been described in this paper, based on the surface area and dry solids content of the TLC. The method is easily implemented and applicable for sprayable TLC coatings.

A facile method for the preparation of large, microporous, drug-loaded particles is presented. High shear bollus injections of silk with cross-linker and drug colloids into super-cooled hexane were utilized to trigger phase separation of silk droplets, followed by immediate freezing at-60 o C. A subsequent-20 o C freeze-thaw of the frozen droplets resulted in self-assembly (crystallization) of the silk. The silk particles developed an internal interconnected microporous morphology with 0.1-10 µm in diameter pores. The silk particles ranged in diameter from 100 to 1,300 µm, with particle mean diameter and polydispersity controlled by the starting concentration of the cross-linking agent and silk, the rheology of the reaction mixture, and the injection pressure (80-300kPa). Cryogranulation provided a one-step process to produce microporous meso-scale silk particles with encapsulated drugs, such as doxorubicin chloride (DoxR), tobramycin sulfate (TS), kanamycin sulfate (KS) or gentamicin sulfate (GS). Almost 100% drug encapsulation efficiency was achieved in the process, and subsequent release profiles depended on the starting concentration of both the drug, silk, and pH of the elution medium. Kirby-Bauer tests and bioluminescent imaging confirmed the retention of anti-bacterial potency of the antibiotics pre-encapsulated in the cryo-particles, and macroparticles cytocompatibility towards human fibroblast and kidney cells.

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