In the present paper, 3-acetyl-5-methoxy-8-methyl-2H,6H-pyrano[3,2-g]chromene-2,6- dione proved to be a useful precursor for synthesis of various 1,3-thiazoles and 1,2,4-thiadiazoles incorporating pyrano[3,2-g]chromene moiety as anticancer agents. The computational studies using MOE 2014.09 software are confirming the results in biological activity.
A new series of 1,3-thiazole-benzofuran derivatives was synthesized via heterocyclization of 2-(1-(6-alkoxy-4,7-dimethoxybenzofuran-5-yl)ethylidene)-2-methyl-2l4-diazane-1-carbothioamides with hydrazonoyl halides. Also, 1-(4,7-dimethoxybenzofuran-5-yl)-3-phenylprop-2-en-1-one derivatives were used for synthesis of another series of 1,3-thiazole-pyrazole-benzofuran. The structure of the newly synthesized products was elucidated via elemental analysis, spectral data, and alternative routes whenever possible. Seven new compounds were evaluated for their anticancer activity against the human breast carcinoma (MCF-7) cell lines compared with doxorubicin drug. The results revealed that some new compounds showed promising anticancer activity.
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