Ethylene bridged azobenzenes are
novel, promising molecular switches
that are thermodynamically more stable in the (Z)
than in the (E) configuration, contrary to the linear
azobenzene. However, their previous synthetic routes were often not
general, and yields were poorly reproducible, and sometimes very low.
Here we present a new synthetic strategy that is both versatile and
reliable. Starting from widely available 2-bromobenzyl bromides, the
designated molecules can be obtained in three simple steps.
A new series of pyrano-chromene and pyrimido pyrano-chromene derivatives were synthesized starting from 2-amino-4-(1-naphthyl)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile (6). The structures of the synthesized compounds were elucidated by spectral data. Compounds 6-11, 13-15 and 18 have been selected for an inhibitory activity screening against HIV-1 and HIV-2 in MT-4 cells.
Arylated quinolines were prepared by Suzuki-Miyaura reactions of 5,7-dibromo-8-(tri-A C H T U N G T R E N N U N G fluoromethanesulfonyloxy)quinoline. The reactions proceed with excellent site-selectivity. The first, second and third attack occur at positions 5, 7 and 8, respectively.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.