The molecular biomarkers, and their correlation with pathological parameters are very important for diagnosis, prognosis, predictive utility, management, and prevention of breast cancer (Patani et al., 2013). The phosphatidylinositol-3-kinase (PI3K) pathway is an important signaling pathway in cells and is involved in essential cellular functions such as metabolism, proliferation, survival, motility, and growth and plays a main role in development and progression of breast cancer (Engelman et al., 2006; Boyault et al., 2012). Based on structure, regulation, and substrate specificity, the PI3K family is classified into three classes, class I, class II, and class III (Leevers et al., 1999). Class I is divided to IA and IB, class IA PI3K is composed of two subunits: A regulatory subunit (85 kDa), and a catalytic

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