This paper presents an experimental work, which carried out to test the feasibility of using dealuminated metakaolin (DaMK) as an additive to metakaolin (MK) in the production of geopolymer concrete. DaMK is produced as a byproduct from the aluminum sulfate industry. The chemical composition and physical properties of DaMK were investigated in this study. Results showed that DaMK is a good pozzolan material, which added to MK by 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, and 70% in producing geopolymer concrete. The compressive strength was measured by testing standard cubes at 7 and 28 days. Satisfactory results are achieved by using 20, 25, 30, 35, and 40% of DaMK. It is recommended to use MK with added proportions of DaMK up to 40% of MK to produce an ecofriendly and economic geopolymer concrete.
DoE is a structured and organised method to determine the relationship between the effect of change in the concentration of the independent variables and its impact on the formulation, through establishing a mathematical model. Since the acceptance of the QbD approach by the regulatory authorities across the world, DoE has been widely implemented in the areas of screening and optimisation of the formulations by the pharmaceutical industries. The topical delivery of API still posses' limitations such as insufficient contact time, odd hours of application time, sticking to fabrics, formulation washing off, etc. To address these limitations, the researcher planned to develop an in situ polymeric sprays that will form a transparent and flexible film, & will not interfere with the applicant's routine. Polymers such as HPMC, Eudragit RS100, PVP K30, PVP K90, Carbopol, Propylene glycol, Soluplus, and pullulan whereas the plasticisers selected were sorbitol. Voriconazole, a second-generation triazole, was used as a model drug. The article is a technological demonstration, in which the screening of polymers as well as the optimised concentration of the polymeric will be selected through 32 factorial design. The aim of the present article is also to establish the relationship between the software response and experimental values. The experiments were designed using 32 factorial design which resulted in 9 trial runs. Each run was evaluated for drying time, viscosity, and stickiness. The resultant response surface Later the optimisation, to yield an optimised polymeric solution that can deliver a desired in situ films. Based on ANOVA comparison of variability due to treatment, the significance of the regression model was evaluated. Other procedures such as DSC, FRIR, Stickiness, pH, diffusion studies were also performed on the selected formulation.
I N this work, geopolymer is produced from two by-products waste as an alternative environmentally green construction and building materials without using Ordinary Portland Cement (OPC). Water Treatment Sludge (WTS) from Marg Drinking Water Treatment Plants in Cairo and De-Aluminated Kaolin (DAK) from Egyptian Company for Aluminum Sulfate were used in this study. Sodium hydroxide (NaOH) solution was used as an alkaline activator. The effect of the various influential factors on compressive strengths of WTS/DAK geopolymer was investigated. These factors are mixing ingredient (WTS/DAK) ratios and amounts of NaOH of different normality. The mineralogical and chemical compositions of the WTS/DAK wastes were obtained using X-ray Diffraction (XRD) and X-ray Fluorescence (XRF) analyses. Results show that the optimum ingredients providing maximum strength are the Na 2 O/SiO 2 ratio of 0.56 and WTS/DAK ratio of 30:70. The development of compressive strengths over curing time of WTS/ DAK geopolymer samples at optimum ingredients (30:70 WTS/DAK, 60 g NaOH 10 N and 70 oC for 72 hours). The compressive strength of WTS/DAK geopolymer gives 17 MPa after 7 days and increased to maximum strength of 22 MPa at 28 days. The compressive strengths obtained comply with the Egyptian Industrial Standards. Moreover, the WTS that traditionally disposed into landfills or drainage canals can be used sustainably in developing cement-free geopolymers with economical and environmental significance.
Objective: Voriconazole (VCZ) is a broad-spectrum antifungal medication that works by inhibiting fungal Cytochrome P450, preventing fungi growth. The current study aims at developing and characterizing an antifungal in situ film-forming polymeric solution spray containing VCZ for use in topical drug delivery systems. Methods: Optimized VCZ in situ polymeric film formulation was evaluated for Fourier transform infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), X-ray diffractometry (XRD), Scanning electron microscope (SEM), in vitro and in vivo, ex-vivo investigation using abdominal rat skin and stability studies. The in vivo antifungal activity of the advanced in situ film was examined in albino Wistar rats. Results: The optimized batch contained 22% Eudragit RS 100 (ERS) and 4% Sorbitol. Based on FTIR, XRD, SEM, and rheological studies. Formulation ingredients of VCZ loaded topical in situ polymeric film spray were observed to be compatible and showed no evidence of precipitation, deformation, or discoloration. Diffusion test (in vitro %), and ex-vivo drug diffusion % obtained 99.22%, and 97.45% respectively. The maximum inhibition zone was measured at 13±0.07 mm. The Wistar rat was employed as an animal model for skin irritation and antifungal studies. A study of short-term stability observed no significant modifications in the physical properties. Conclusion: The findings of the optimized VCZ topical in situ polymeric film spray formulation were satisfactory, demonstrating comparable improvement in superficial antifungal treatment.
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