BackgroundDue to the Total Mesorectal Excision (TME) surgery made a good local control,the role of radiotherapy in the treatment of pT3N0 rectal cancer is debated and whether this group of patiens were overtreated has been a controversy recently. This study aimed to evaluate the value of adjuvant radiation after TME and survival outcome for patients with pT3N0 rectal adenocarcinoma.MethodsFrom January 2003 to December 2011, a total of 141 patients with pT3N0 rectal cancer after radical resection with the principle of Total Mesorectal Excision (TME) were enrolled. Among them, 42 patients (29.8%) got adjuvant chemotherapy (CT) and the remaining cohort received chemoradiotherapy (CRT). The 5-year overall survival rate (OS), 5-year disease free survival rate (DFS), 5-year local recurrence free survival rate (LRFS), 5-year local recurrence rate (LRR) and the prognostic factor of this cohort were analyzed.ResultsThe median follow-up interval time was 44 months. The 5-year OS and DFS rates were 82.4% and 71.9% for the whole group. There were no significant differences in 5-year OS (83.3% vs 72.4%, P = 0.931) or LRFS rates (81.7% vs 74.5%, P = 0.157) for patients between CT group and CRT group. Multivariate cox regression analysis suggests that preoperative serum CEA level, number of lymph nodes inspected, perirectal fat infiltration were independent prognostic factors for 5-year DFS. The recurrence rate was not affected by radiotherapy for patients with lower and midrectal cancer.ConclusionsFor the patients with pT3N0 rectal cancer, addition radiation after TME surgery made no significant differences in survival rate and local recurrence rate. The effect of adjuvant radiotherapy needs further evaluation.
Silicon substrate on-chip (SSOC) supercapacitors have recently attracted considerable attention in electronic devices because of their compatibility with the current silicon-based micro- and nanofabrication processes. However, the low-energy density of the silicon substrate supercapacitors largely restricts their practical applications. Herein, in situ polymerization of coral-like polyaniline (PANI) was performed over the surfaces of aligned silicon nanowires (SiNWs) prepared by the metal-assisted chemical etching process. Especially, the coral-like morphology of the PANI over the aligned SiNWs (PANI@SiNWs) is regulatable with the control of the concentration of the aniline monomer. After systematical structural characterization of PANI@SiNWs by field emission scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectrometry, and Raman spectroscopy, it is confirmed that the coral-like morphology provides higher specific surface area and more effective charge transport channels, which essentially benefits the exchange of the aqueous electrolytes on the surface of the electrode to improve the electrochemical performances of the material. Therefore, compared to individual PANI and SiNWs, the prepared PANI@SiNW-based supercapacitor electrode exhibited a much higher areal capacitance of ∼95 mF/cm2 at a scan rate of 10 mV/s. The obtained PANI@SiNW electrode exhibited reliable stable cyclability with a capacitance retention of 71.8% of the initial value compared with pure PANI. The presented work demonstrates a feasible approach to improve the areal capacitance value of SSOC supercapacitors.
Background Threatened preterm labor (TPL) is an important obstetrical challenge. Pregnant women with TPL may develop psychological and physical problems such as mental health disorders, sleep disturbance, and hormonal circadian rhythm disruption. This study aimed to investigate the current state of mental health, sleep quality, and circadian rhythms of cortisol and melatonin secretion in pregnant women with TPL and normal pregnant women (NPW). Methods A prospective observational clinical study was conducted at a maternal and child health hospital in Fuzhou, China, between June and July 2022. A total of 50 women between 32 and 36 weeks of gestation (TPL group, n = 20; NPW group, n = 30) were recruited. Data on anxiety symptom (Zung’s Self-rating Anxiety Scale, SAS), depression symptom (Edinburgh Postnatal Depression Scale, EPDS), subjective sleep quality (Pittsburgh Sleep Quality Index, PSQI) and objective sleep outcomes (measured by actigraphy) of the pregnant women were collected at the time of enrolment. Salivary samples were collected once every 6 h (i.e., at 06:00, 12:00, 18:00, and 00:00) during 2 consecutive days to measure the circadian rhythm of hormone (cortisol and melatonin). Results There were no differences found in the total scores of SAS, EPDS scores, subjective sleep quality between the TPL and NPW groups (P > 0.05). In contrast, significant differences were found in sleep efficiency, total sleep time, wake time after sleep onset, and average awakening time between the groups (P < 0.05). The circadian rhythm of melatonin secretion was disrupted in the TPL group (P = 0.350); however, it was maintained in the NPW group (P = 0.044). The circadian rhythm of cortisol secretion was disrupted in both groups (P > 0.05). Conclusions In the third trimester of pregnancy, women with TPL suffer from poorer sleep quality and disruption of circadian rhythm of melatonin secretion compared with NPW. Nevertheless, there were no differences found in mental health (i.e., anxiety and depression) and circadian rhythm of cortisol secretion. Large-scale studies should be conducted to evaluate these changes in women with TPL. Trial registration The study was registered from Chinese Clinical Trial Registry (Number: ChiCTR2200060674) on 07/06/2022.
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