The site of the emetic action of digitalis and related compounds has been a subject of considerable research and controversy over a period of more than 30 years. The initial conclusions of Hatcher and Eggleston,l**J that the effect was of central rather than peripheral origin, were not borne out by later studies.4VGHatcher and we is.^*^^^^ and Hatcher and FrenchR suggested that the emetic response to digitalis was of a reflex nature initiated by afferent impulses arising in the heart. This was later questioned by Dresbach and Waddell,f'JOJ1 and by Haney and Lindgren.12 The latter authors conclude that the mechanism must lie either in a direct action on the medullary center, as originally suggested, or "on other structures from which impulses pass to the center via nerves other than those elim-* The author is indcbted to Dr. H. 13. Raag for his valuable counwl during tlic course of this work and to Dr. E. L. Siiiitli who assisted with the surgical procedurcs. 1 Hatcher, R. A., aiid Egglestoii, Cary, .7. P71nrmacol. Exp. Themp., 1913, 4, 113. 2 Eggleston, Cary, :ind IIatchcr, R. A., J. A . M.
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