The thiocarbonyl group offers broad possibilities for the synthetic chemist. As a result of its ready polarizability it acts as an a 0 , a 1 , d 0 , and even a d 1 synthon [2]. In addition many 4-quinolones possess high biological activity. In view of this the development of methods of synthesizing thioaldehydes and thioketones, and also 4-quinolones is an urgent problem. N R N N N N N Me N N R S 1a-e 4 3a-e 2a I S/KOH S 3a -+ DMF DMF + 1, 3 a R = Me, b R = Et, c R = Bu, d R = CH 2 CH 2 CHMe 2 , e R = CH 2 Ph
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