This generic STR TDF/3TC/EFV is effective and well-tolerated. These findings lend support to the use of this generic STR as first-line antiretroviral therapy in resource-limited settings.

PR treatment has comparable response rates and toxicity profile in Thai HIV/HCV co-infected patients as in Western HIV/HCV patients. However, ribavirin plasma concentrations were comparable with previously published studies in HIV/HCV co-infected patients, but both, just as SVR rate, were lower than in mono-infected patients.

Background: APOBEC3G potently controls HIV replication by introducing G-to-A hypermutation. Genetic variants of APOBEC3G, 186H/R is associated with HIV/AIDS disease progression in adults. However, the details of its effect in children remain unclear.Methods & Materials: Rapid progressors (RPs) was defined as children who had AIDS-related symptoms (PCP, HIV encephalopathy) before their second birthday. Long-term non-progressors (LTNPs) were defined as children, aged>8 years, maintaining CD4%≥25%, and without cART. RPs and LTNPs were of 630 perinatally infected children who were enrolled in the multicenter studies of Thailand and Cambodia.APOBEC3G genotypes were determined by PCR-restriction fragment length polymorphism method using genomic DNA samples. APOBEC3G-mediated hypermutations were analyzed by sequencing of the vif/vpu genes from proviral DNAs.Results: A total of 14 RPs and 24 LTNPs were enrolled. 50% of RP and 67% of LTNP were female (p=0.3). Median ages at sample collection were 11.