The aim of the work was to demonstrate the possibility of forming a strategy of innovative development of the region that could accelerate the transition of the regional economy to the dominance of new technological structures. By constructing econometric models of economic dynamics, the timelines for starting the pre-mining of the fifth mode in the economy of the Tula region are estimated. The strategy of accelerating the innovative development of the region’s economy are described. The strategy is based on the program-target approach, reflected in the state program of industrial development in the Tula region. The effectiveness of the program is shown.
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