An efficient and concise stereoselective synthesis towards the antimalarial (−)‐Gomphostenin, starting with the enantiomerically pure Wieland–Miescher ketone, is reported. The key transformations of the convergent synthesis involved a stereoselective reductive allylation, Palladium‐catalyzed Saegusa–Ito oxidation, Babler–Dauben oxidative rearrangement, and Wittig olefination reactions. The structure and absolute stereochemistry were determined by X‐ray analysis.
A concise approach for the total synthesis of attenols A (I) and B (II) is described involving MacMillan α‐aminooxylation, Evans′ asymmetric alkylation, Brown allylation, and spiro‐ketalization as key steps.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.