'hypertrophy' conditions. Conventional echocardiographic systolic and diastolic parameters are often non-specific. We attempt to evaluate the use of diastolic strain analysis to identify pathological LV 'hypertrophy' conditions. Methods: We retrospectively analysed 19 patients (13 men, mean age 64 614 years). 14 of them have different [left ventricular wall 'hypertrophy' conditions (hypertrophic cardiomyopathy, n=5; cardiac amyloidosis, n=3; chronic pressure overload conditions (hypertension and aortic stenosis), n=5; Anderson-Fabry disease, n=1. Their baseline demographic, systolic and diastolic strain parameters were analysed in comparison to a healthy cohort (n=5). Results: There was no significant difference between LV ejection fraction (Control, 6264 vs Study, 6168%, p=0.79). Global longitudinal strain is reduced in the study group, but it is not statistically significant (19.262.4% vs 12.6268.62%, p=0.09). There was a significant reduction in early global diastolic strain rate (1.160.28 vs 0.5760.33, p =0.005), late global diastolic strain rate (0.7760.27 vs 0.4360.23, p=0.0146), global diastolic strain rate at isovolumetric relaxation (0.7260.19 vs 0.2960.21, p,0.001). The ratio of the Doppler E-velocity over early global diastolic strain rate is significantly higher (71634 vs 1736100, p=0.042). Conclusion: Diastolic strain analysis may have an incremental utility to identify LV 'hypertrophy' conditions.
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