Toxicity of a material upon placement in patient's oral cavity triggers the immune system to elucidate an appropriate response. Thus, one of the many fundamental responsibilities bestowed on the dentist is to shield patients from any untoward reaction. A plethora of dental materials is currently available in the market. The material has to advance several tests in order to be safely introduced for clinical practice. This review highlights the spectrum of tests routinely practiced for evaluation of biocompatibility.
The halogen atoms on various positions of the N-arylamino ring played an advantageous role in elevating the potency of the molecules. Thus, these conjugates could be used as a lead for further optimization to achieve promising therapeutics.
In the present study, we describe the design and expeditious synthesis of novel 2-aryl-5-(3-aryl-[1,2,4]-oxadiazol-5-yl)-1-methyl-1H-benzo[d]imidazole hybrid molecules as promising antimicrobial agents.
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