The series of organotin halide complexes with tetraethyl ethyleneand propylenediphosphonates R,SnX4-,-L [n=O, X=CI; n=1, R=Me, X=CI, Br; n=1, R=Ph, X=C1; n = 2 , R=Me, Et, Bu, X=CI, Br; n = 2 , R=Ph, X=CI; L = (EtO),P(O)CH,CHR'P(O)(OEt),, R' = H, Me] were synthesized and characterized by means of NMR and Mossbauer spectroscopy. The crystal structure of the complex of diphenyltin dichloride with propylenediphosphonate was determined. The complex consists of polymer chains with bridging bidentate ligands and an octahedral tin environment containing two types of phosphoryl fragments. All of the R2SnX, adducts have trans-R,SnX, geometries of tin coordination octahedra according to the quadrupole splitting values in the Mossbauer spectra. The 31P and 'I9Sn NMR studies at low temperatures revealed that RSnHal, complexes in solution form isomers with different mutual orientations of phosphoryl ligands and organic groups in the coordination sphere. The diethyltin dichloride adduct with ethylenediphosphonate appeared to be active against lung cancer NCI-H522 cells.
Analysis of literature data on the antitumor activity of organotin compounds reveals that R2SnX2 and their complexes containing SnO, SnN or SnS bonds often exhibit biological activity, especially if such bonds are formed by means of intramolecular coordination. Furthermore, a wide range of biological activities, from fungicidal, bactericidal and antiseptic to psychotropic and antitumor, is found to be characteristic for some organic hydroxamic acids (N‐acylhydroxylamines). From this point of view the diorgantion bis‐hydroxamates in this paper are of particular interest as potential biologically active antitumor drugs. Di‐n‐butyltin bis(N‐methyl‐N‐p‐bromobenzoylhydroxylamine) is being screened for antitumor activity.
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