The effect of methallibure, a non-steroidal pituitary inhibitor, on the hypersecretion of gonadotrophins in parabiotic rats after castration of one partner has been investigated. At lower doses the compound prevents the hypertrophy of the ovaries in the intact partner. At higher doses it may cause a decline in the ovarian weight of the intact partner.
SUMMARY
The effect of methallibure, a non-steroidal pituitary inhibitor, on the growth and nitrogen retention of young rats treated with ovine growth hormone has been studied. Growth hormone induces nitrogen retention and body growth and this effect was suppressed by the simultaneous administration of methallibure. The possibility that the drug acts as an antimetabolite is discussed.
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