Purpose: Injectable long‐acting implant of Fluocinolone Acetonide (FAc) has proven useful for the treatment of macular edema of different etiologies. The aim of our study was to assess the real‐life safety and efficacy of FAc 0.19 mg intravitreal implant for the treatment of macular edema.
Methods: We retrospectively collected data from all patients with macular edema prescribed with FAc intravitreal implant between January 2019 and May 2022 in a single tertiary hospital. Central retinal thickness (CRT), visual acuity (VA), intraocular pressure (IOP) and need for cataract surgery were measured as the endpoints of interest at baseline and were reevaluated every 3 months.
Results: Finally, 41 patients, contributing 51 eyes, were included in the analysis. Most frequent indication for prescription was macular diabetic edema (n = 33, 64.7%), followed by uveitis (n = 9, 17.6%) and others (iris‐supported phakic intraocular lens, retinal vein occlusion, Irvinne Gass syndrome and post‐retinal detachment surgery; n = 9, 17.6%). In terms of efficacy, at a median follow‐up of 20.3 months, a reduction in CRT was observed (from 438 μm to 299 μmat at 12 months) and this resulted in an improvement in VA (from 0,30 to 0,41 at 12 months), mostly in uveitis group. In terms of safety and secondary effects, no endophthalmitis was reported and IOP increased at follow‐up with 20 eyes requiring topical IOP‐lowering drops. All phakic eyes at baseline (n = 10, 19.6%) were referred to cataract surgery in the follow‐up, at a mean of 13 months after FAc injection.
Conclusions: FAc intravitreal implant for the treatment of macular edema in real‐life patients resulted in improvement of both CRT and VA with predictable secondary effects and no major safety concerns.
Background:Perfusion of the optic nerve has been widely studied using fluorescein angiography (FAG), which is currently regarded as the criterion standard. However, FAG has adverse effects associated with intravenous contrast administration and is limited in its capacity to characterize and stratify the different vascular layers of the optic nerve and retina. The use of new imaging techniques, such as optical coherence tomographic angiography (Angio-OCT), is therefore important.Aim:A qualitative description is made of the vascular layers of the optic nerve and of how vascular events affect radial peripapillary capillaries (RPC). Two patients with central retinal artery occlusion (CRAO), 1 with arteritic anterior ischemic optic neuropathy (AAION), and 3 healthy subjects were studied.Results:The Angio-OCT imaging afforded better visualization of the depth of the RPC and rest of the vascular layers of the retina compared with FAG. Optic nerve surface perfusion was affected in AAION and proved normal in CRAO.Conclusions:Our results indicate that perfusion of the papilla and RPC mainly arises from the papillary plexus that depends on the posterior ciliary artery.
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