<zakljucak> Prelomno otkrice nedostatka hipokretina kod narkolepsije pruza izvrsnu osnovu za bolje razumevanje fiziologije spavanja i podsticaj je za buduca istrazivanja. Medjutim, ono nije omogucilo da se razresi enigma etiologije narkolepsije. Za razliku od animalnih modela, narkolepsija kod ljudi, mada specificno povezana sa deficitom hipokretina, nije samo jednostavan genski poremecaj. Mehanizam regulisanja ekspresije gena za preprohipokretin tek treba da bude razjasnjen.
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