Non-specific low back pain can seriously decrease the health-related quality of life. In the search for treatment modalities which are inexpensive and effective, isotonic sugar water injections have received more attention among clinicians worldwide. Physicians have been injecting sugar water epidurally, perineurally and into soft tissues such as muscles and ligaments. In this article, it is hypothesized that isotonic sugar water injections can be a new tool to manage patients with non-specific low back pain originating from muscles and ligaments. Especially shallow injections into muscles and ligaments are interesting for some physicians as these techniques do not require radiological guidance.