The aim: To analyze the epidemiological data and clinical course of pneumonia as a complication of influenza in the Poltava region, depending on the etiological agent.
Materials and methods: We have analysed the data of the official reporting documentation provided by the State Institution “Poltava Regional Laboratory Center of the
Ministry of Health of Ukraine” and the chart of patients with a laboratory confirmed diagnosis of influenza who were in inpatient treatment at the Poltava Regional Clinical
Infectious Hospital (PRCIH) in 2016-2018 years. In more detail, we examined 95 patients with pneumonia, which complicated the course of the flu. There were 43 (45.26%)
female patients, − 52 (54.74%) male patients, aged 18 to 80 years.
Results: Studies have shown that despite a decrease in the incidence of influenza in recent years, the incidence of pneumonia, which complicated the course of the flu, remained
consistently high (19.7% – 20.8%) with bacteriological isolation of S.pneumoniae (22.11%), S.aureus (13.68%), Haemophilus influenza (4.21%) and E.coli (3.16%). Severe course
of pneumonia with bloody sputum, evident shortness of breath, bilateral lung damage, and need for oxygen support were significantly more frequently reported in patients
with isolated S.pneumoniae and S.aureus. However, the severe course of the disease with the formation of abscesses in the lungs was observed only in the group S.aureus despite
the relatively young age of such patients and significantly fewer risk factors for severe influenza and comorbidities.
Conclusions: The study showed a consistently high incidence of pneumonia, which complicated the flu and caused by S.pneumoniae, S.aureus, Haemophilus influenza and
E.coli. Pneumonia caused by S.pneumoniae and S.aureus, were characterized the most severe course; however, a severe course with the formation of abscesses in the lung tissue
was observed only in the group of S.aureus.
KEY WORDS: influenza-associated pneumonia, etiological structure, risk factors, clinical features
West Nile Fever (WNF) is the most common arbovirus infection caused by West Nile Virus (WNV), which has been responsible for numerous epidemic outbreaks of disease among humans, birds and horses on all continents, with the exception of Antarctica, over the past two decades. On the territory of Ukraine, the earliest reports of cases of WNV circulation in humans and birds relate to the 70s of the XX century. In Poltava region WNF was first registered in 2011. Though the epidemiological and clinical patterns of WNF in Ukraine and Poltava region remain understudied, primarily due to the lack of alertness of practitioners to the problem of WNF and to broader access to laboratory diagnosis of the disease. The first clinical case of West Nile Viral encephalitis, registered on the territory of Poltava region, has been given and analyzed.
Цель работы − проследить связь полиморфизма Arg753Gln гена TLR-2, Leu412Phe гена TLR-3, Asp299Gly гена TLR-4 со склонностью к воспалительным заболеваниям верхних и нижних дыхательных путей и развитием осложненных форм ОРИ. Материалы и методы. Связь полиморфизма генов Arg753Gln TLR-2, Leu412Phe TLR-3, и Asp299Gly TLR-4 с воспалительными заболеваниями верхних и нижних дыхательных путей изучили у 98 практически здоровых лиц, которые были распределены в зависимости от генотипа TLR-2, TLR-3, TLR-4. Генотипирование полиморфного участка Arg753Gln гена TLR-2, Asp299Gly гена TLR-4, Leu412Phe гена TLR-3 проводили методом полимеразной цепной реакции с использованием
Medical Stomatological Academy», which promotes the continuous medical education, is one of the mechanisms for improving the quality of professional training and has economic efficiency. Under the conditions of intensive development of information technologies, further perspectives have been considered.
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