Objective To investigate whether discontinuation of oxytocin infusion increases the duration of the active phase of labour and reduces maternal and neonatal complications.Design Randomised controlled trial.Setting Department of Obstetrics and Gynaecology, Regional Hospital of Randers, Denmark.Population Women with singleton pregnancy in the vertex position undergoing labour induction or augmentation.Methods Two hundred women were randomised when cervical dilation was ≤4 cm to either continue or discontinue oxytocin infusion when cervical dilation reached 5 cm.Main outcome measures The primary outcome was duration of the active phase of labour, defined as the time period from 5 cm of cervical dilation until delivery. Secondary outcomes were mode of delivery, uterine tachysystole, hyperstimulation, abnormalities in fetal heart rate, postpartum haemorrhage rate, perineal tears, and neonatal outcomes.Results The active phase of labour was longer by 41 minutes (95% confidence interval 11-75 minutes) in the discontinued group (median 125 minutes in 85 women who had reached the active phase and delivered vaginally) versus the continued group (median 88 minutes in 78 women). The incidence of fetal heart rate abnormalities (51 versus 20%) and uterine hyperstimulation (12 versus 2%) was significantly greater in the continued than the discontinued oxytocin group. The incidence of tachysystole, caesarean deliveries, postpartum haemorrhage, third degree perineal tears and adverse neonatal outcomes was higher in the continued group, but did not reach significance.Conclusions Discontinuation of oxytocin infusion in the active phase of labour may improve some labour outcomes but has the disadvantage of increasing the duration of the active phase of labour.Keywords Active phase of labour, caesarean delivery, discontinuation of oxytocin, fetal heart rate abnormalities, hyperstimulation.Tweetable abstract Stopping oxytocin in the active phase seems to make labour less complicated but lengthens duration.Please cite this paper as: Bor P, Ledertoug S, Boie S, Knoblauch NO, Stornes I. Continuation versus discontinuation of oxytocin infusion during the active phase of labour: a randomised controlled trial. BJOG 2016;123:129-135.

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During the period 1987-1992, 99 patients with benign bladder tumours were followed regularly with transabdominal ultrasound of the bladder and out-patient flexible cystoscopy. Thirty-five patients had recurrent bladder tumours, but in only one case was there progression to invasive tumour. Seventy-six per cent of the recurrences were diagnosed by flexible cystoscopy while 22% were found by ultrasound. Compared to conventional follow-up programs with in-patient rigid cystoscopy the combination of ultrasound and flexible cystoscopy proved to be safe, highly acceptable by the patients and cost-effective.