In most volume of distribution (V D) determinations the drug partitioned in to erythrocytes (C ery) occupying 45% of blood volume is disregarded. The V D determinations can be erroneous on two accounts. The first is the indiscriminate reference to plasma (C p) , whole blood (C b) or serum (C s) concentrations. The second is when C ery values are not considered in calculations. Isolated erythrocytes were incubated in plasma water (C pw) represented by physiological saline drug solutions, the C pw , C ery and C b values were experimentally determined in vitro. Aberrations to the V D determinations are demonstrated using both theoretically and practically determined values of C pw , C ery and C b. Widely varying V D values 125 L to 2.55 L resulted when C p data alone is used while the values differed marginally from 4.56 L to 5.53 L when C b values were used for two setting using same amount of drug.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.