On the basis of tests for specific IgM class antibodies in the serum, infections by hepatitis A virus, hepatitis B virus and hepatitis non‐A, non‐B virus accounted for 7%, 37.8% and 54.2% respectively of 286 cases of acute sporadic viral hepatitis in adults from three different regions of India. Epstein‐Barr virus and cytomegalo virus were insignificant (0.5–1%) aetiological agents. Approximately one‐quarter of all non‐A, non‐B (NANB) cases were additionally HBsAg carriers; there were significant differences in regional frequencies. NANB hepatitis commonly affected individuals in the mid‐fourth decade and occurred throughout the year with small peaks in different seasons. No antigen‐antibody reaction could be demonstrated in various immunological tests including radioimmunobinding using acute and convalescent phase sera. Neither were virus‐like particles visualized in acute phase sera on electron and immuno‐electron microscopy. However, rhesus monkeys inoculated with acute phase serum from a case of NANB hepatitis developed distinct hepatocellular changes at 43–55 days after inoculation, which had some features of similarity with experimental NANB hepatitis of other simian species. Sporadic NANB hepatitis is a major health problem throughout India and intensive study is needed on its epidemiology and aetiology.
By the use of the Crosby-Kugler capsule jejunal mucosal biopsies have been obtained from patients with various skin disorders and non-diarrhoeal gastrointestinal diseases. A preliminary report is presented regarding the correlation between stereomicroscopic and light microscopic findings.Cutaneous manifestations of internal disease are well known topics of common interest and scientific investigation. The subject interests not only dermatologists, but also workers of other disciplines of medicine. Much interest is currently being evinced on the inter-relationship between skin manifestations and alimentary disorders and there is much speculation as to whether these conditions are causally related or coincidental. Wells (1962) was probably the first to publish in recent times a review of skin diseases in relation to malabsorption. He relates a number of dermatoses -• including eczema, acrodermatitis enteropathica, exfoliative dermatitis, psoriasis and pigmentation-to small bowel disorders. Watson et al. (1965) observed abnormal jejunal mucosae in 33% of patients with rosacea. Sinister and Marks (1965) demonstrated that widespread skin disease could be associated with steatorrhaja which is reversible on clearing up the skin disease to which they gave the name "dermatogenic enteropathy". Hindle and Creamer (1965) suggested that a common cause may operate for both the skin and intestinal changes at the same time.The mucosa of the small intestine has since been extensively studied by Fry et al. (1966) in eczema, psoriasis and ichthyosis; Sinister et al. (1967) in psoriasis andMarks et al. (1966) in dermatitis herpetiformis. It is of interest that in a subsequent publication Marks and Sinister (1970) commented that contrary to their earlier recordings, the frequency of the abnormal small intestinal mucosal appearance observed at stereomicroscopy in psoriasis is not significantly different from that observed in a control group.Apart from the study of the morphology of the jejunal mucosa, there has always been the difficulty of finding a simple and reliable screening test for malabsorption in office practice, particularly so, in skin diseases. Knowles et al. (1963) have pointed out that FIGLU test is frequently positive in patients with skin disease, the folic acid deficiency being probably due to the increased demand for the substance by the skin rather than due to
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.