Estimating the depth of anesthesia (DOA) is still a challenging area in anesthesia research. The objective of this study was to design a fuzzy rule based system which integrates electroencephalogram (EEG) features to quantitatively estimate the DOA. The proposed method is based on the analysis of single-channel EEG using frequency and time domain methods. A clinical study was conducted on 22 patients to construct subsets of reference data corresponding to four well-defined anesthetic states: awake, moderate anesthesia, surgical anesthesia and isoelectric. Statistical analysis of features was used to design input membership functions (MFs). The input space was partitioned with respect to the derived MFs and the training data was used to label the partitions and extract efficient fuzzy if-then rules. Consequently, the fuzzy rule-base index (FRI) is derived between 0 (isoelectric) to 100 (fully awake) using fuzzy inference engine and designed output MFs. We also applied the same features to an adaptive network-based fuzzy inference system (ANFIS) derived without any prior knowledge. The results show that FRI correlates more with the clinically accepted DOA index, CSI TM (CSM, Danmeter, Denmark). In addition to this achievement the main idea behind this study is to simplify the mutual knowledge exchange between the human expert and the machine, leading to enhance both interpretability of the results and performance of the system.
Various EEG features have been used in depth of anesthesia (DOA) studies. The objective of this study was to find the excellent features or combination of them than can discriminate between different anesthesia states. Conducting a clinical study on 22 patients we could define 4 distinct anesthetic states: awake, moderate, general anesthesia, and isoelectric. We examined features that have been used in earlier studies using single-channel EEG signal processing method. The maximum accuracy (99.02%) achieved using approximate entropy as the feature. Some other features could well discriminate a particular state of anesthesia. We could completely classify the patterns by means of 3 features and Bayesian classifier.
BackgroundThe importance of proper qualitative evaluation of EEG parameters during surgery has been recognized since many years. Although none of the characteristics based on the frequency, entropy, and Bi spectral characteristics have been regarded as a good predictor for detection of the depth of anesthesia alone. So it seems necessary to study multiple characteristics together.ObjectivesIn this study we tried to introduce the best combination of the mentioned characteristics.Materials and MethodsEEG data of 64 patients undergoing general anesthesia with the same anesthesia protocol (total intravenous anesthesia) were recorded in all anesthetic stages in Shohada Tajrish Hospital. Quantitative EEG characteristics are classified into 4 categories: time, frequency, bi spectral and entropy based characteristics. Their sensitivity, specificity and accuracy in determination of the depth of anesthesia are yielded by comparison with recorded reference signal in awake, light anesthesia, deep anesthesia and brain death patients. Then, with combining 2, 3, 4 and 5 of characteristics and using coded algorithm we determined the error degree and introduced the combination yielding the least error.ResultsFifteen vectors (of dimension two to five) which yielded the best results were introduced. Vectors combined of entropy based characteristics obtained 100% specificity and sensitivity during all 4 stages.ConclusionsThe combination entropy based characteristics had high accuracy in predicting the depth of anesthesia. Reevaluation of classic indices cortical status index and BIS seems necessary. The next step is to find a system to simplify the evaluation of this information for technicians.
Background: Evaluation of depth of anesthesia is especially important in adequate and efficient management of patients.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.