Cellular senescence-inhibited gene (CSIG) protein, a nucleolar protein with a ribosomal L1 domain in its N-terminus, can exert non-ribosomal functions to regulate biological processes, such as cellular senescence. Here, we describe a previously unknown function for CSIG: promotion of apoptosis in response to ultraviolet (UV) irradiation-induced CSIG upregulation. We identified p33ING1 as a binding partner that interacts with CSIG. After UV irradiation, p33ING1 increases its protein expression, translocates into the nucleolus and binds CSIG. p33ING1 requires its nucleolar targeting sequence region to interact with CSIG and enhance CSIG protein stability, which is essential for activation of downstream effectors, Bcl-2-associated X protein, to promote apoptosis. Thus, our data imply that p33ING1–CSIG axis functions as a novel pro-apoptotic regulator in response to DNA damage.

WE43 magnesium alloy has been considered as a promising candidate material for biodegradable coronary stents. In order to evaluate the effects of blood flow on the corrosion process of biodegradable Mg and its alloys, the corrosion behaviours of as cast pure Mg and as extruded WE43 alloy in Hank's solution under three different conditions, i.e. static, stirring and flowing, were investigated in the present work. We found that the as cast pure Mg exhibited much higher corrosion rate than the as extruded WE43 alloy regardless of the liquid flowing condition of the solution. Both pure Mg and WE43 alloy samples exhibited the lowest corrosion rate under the stirring condition while the flowing condition promoted local corrosion with the corrosion rates three to six times faster. The results of this study suggest that static immersion may be not proper to predict in vivo corrosion rates of magnesium alloy stents.

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The prevalence of psychiatric disorder in adults with ID was strikingly higher than that in the general population. Health service utilisation among Chinese adults with ID remained a big challenge. There is a possibility of diagnostic overshadowing by local clinicians, which may have resulted in overdiagnosis of dementia and underdiagnosis of common mental disorders. This study informs further investigations regarding common mental disorders among people with ID and has implications for public health strategies and health policies to meet health service need for this population.