New biodegradable amino acid based biodegradable (AABB) ester polymers having a potential for constructing resorbable surgical and therapeutical devices were synthesized by solution step-growth polymerization (SGP) of bis-azlactones (BALs) with dip -toluenesulfonic acid salts of bis-(α-amino acid)-α,ω-alkylene diesters (TDADEs). Relatively low-molecularweight homopolymers-poly(ester amide)s with Mw within 2,800-19,600 Da (GPC in DMF) were obtained. To increase molecular weights of the goal AABB ester polymers two additional synthetic strategies were appliedeither activated diester such as dip -nitrophenyl sebacate was used as a comonomer of BAL, or alkylene diamine such as 1,6-hexamethylenediamine was used as a comonomer of TDADE. As a result high-molecular-weight AABB ester polymers with Mw up to 103,500 Da were synthesized depending on co-monomers' structure and mole ratios. All the BAL-based polymers obtained after SGP were practically[J1] amorphous. The thermograms (DSC) of the polymers made of the BAL F showed wide endotherms within 55-120 o C. These endotherms were assigned to melting hydrophobic domains formed by highly hydrophobic fragments-residues of phenylalanine-based bis-azlactone (BAL F) in the polymeric backbones. The obtained new BAL-based ester polymers substantially expands a family of AABB polymers destined for constructing resorbable surgical and pharmaceutical devices.
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