A simple, fast, specific, and precise high-performance thin layer chromatography method has been developed for the estimation of monosodium l-glutamate (MSG) in food products. Aluminum plates precoated with silica gel 60 GF254were used as stationary phase and a mixture of methanol–chloroform–formic acid in the ratio 5:5:1 (v/v) as mobile phase. Quantification was carried out by postchromatographic derivatization using 1% ninhydrin solution, and the developed spots were scanned by using a densitometer in absorbance mode at 485 nM. The Rfvalue of MSG was 0.64. The results of the analysis have been validated statistically and by the recovery studies. Linearity was observed in the concentration range of 400–1000 nG.

Topical drug delivery has been used for centuries for the treatment of local skin disorders. Drugs applied to the skin for their local action include antiseptics, antifungal agents, skin emollients, and protectants. Major disadvantage of gel is the delivery of hydrophobic drug. This can be overcome by emulgels. Emulgels have emerged as one of the most attractive topical delivery system as it has dual release control system i.e. gel and emulsion. Since hydrophobic drugs are not soluble in gel bases, it causes problem during the release of drug. When gel and emulsion are used in combination the dosage form is referred as emulgel. In emulgel formulation, the hydrophobic drugs could be incorporated into the oil phase and then oily globules are dispersed in aqueous phase resulting in o/w emulsion which can be mixed into the gel base. The major aim behind this formulation is delivery of hydrophobic drugs to systemic circulation via skin. A distinctive feature of topical drug delivery is the straight accessibility of the skin as a target organ for the treatment. This might be proving improved stability and release of drug than just incorporating drugs into gel base. The purpose of this review article is to exemplify emulgel for topical drug delivery, advantages and disadvantages of emulgel, physiology of skin, major components of emulgel, method of preparation, characterization and marketed products of emulgel.

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Losartan is used to treat high blood pressure (hypertension) and also used to lower the risk of stroke in certain people with heart disease. Therefore, the purpose of this study is to formulate mouth dissolving tablet of losartan potassium to improve its bioavailability, to attain fast onset of action and rise patient compliance. Owing to short bioavailability of 33% and to increase onset of action, fast dissolving tablets of Losartan Potassium were formulated using coprocessed superdisintegrants in order to improve the dissolution rate, in that way the bioavailability. The effect of concentration of the Croscarmellose sodium was studied by a set of three formulations (F1, F2, F3) with concentrations of 2%, 4% and 8% w/w respectively. Similarly, the impact of Sodium Starch Glycolate was studied by a set of three formulations (F4, F5 and F6) respectively. The formulation prepared with 8% w/w of superdisintegrant showed relatively rapid release of Losartan potassium when compared with other concentrations of Croscarmellose sodium and Sodium Starch Glycolate. The formulation prepared with Croscarmellose sodium had showed relatively fast release of Losartan Potassium when compared with Sodium Starch Glycolate. Three formulations (F7, F8 and F9) were prepared by including a combination of superdisintegrants (Co-processed Mixtures), Croscarmellose sodium and Sodium Starch Glycolate by direct compression method. Formulation containing Co-processed mixtures had less disintegration time as compared to the individual superdisintegrants. Subsequently, we can conclude that nature, concentration of the superdisintegrant in addition to combination of superdisintegrants (Co-processed) showed influence on the rate of dissolution.