The presence of four iodine atoms in the molecule of thyroxine directed our attention to the problem of determining its crystal structure.Samples of thyroxine and sodium thyroxine were kindly supplied by Dr A. B. Hems of Glaxo Laboratories, Greenford, Middlesex. As the DL-sodium salt was found to crystallize more readily and to form better crystals, it was decided to start work on that compound. Its chemical formula is I I I HO--~O-~,-CH2-CH(NH~)COONa • 5H~O.
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