This open-label study suggests the therapeutic efficacy of high-intensity LED pure blue light in the treatment of acne vulgaris with no reported side effects.
The association of psoriasis with HLA-B13, B17, and CW6 in Caucasians is well established (White et al, 1972;Russell, Schultes & Kuban, 1972;Svejgaard et al, 1974;Batchelor & Morris, 1978;Tiilikainen et al, 1980). However, more recent data suggest that these associations may be secondary to an association of the disease with DR7 (Tsuji et al, 1979;Raffoux et al, 1980). This report presents data supporting the association of serologically defined HLA-DR (D related) antigens with psoriasis.
METHODSSixty-nine Caucasian patients, all attending the psoriasis treatment clinic at UCLA Dermatology Centre, together with 218 Caucasian controls, were tested for a range of HLA-A and B antigens, and for six HLA-DR antigens using a standard microcytotoxicity test (Terasaki et al, 1978). Due to nonavailability of antisera, patients and controls were not typed for CW6.
PatientsThe sixty-nine patients were all interviewed and examined by a dermatologist (N.J.L.) to determine age at onset of psoriasis, presence or absence of family history, and presence or absence of psoriatic arthritis. All patients were suffering from psoriasis vulgaris and all had presence of, or a history of, plaques of psoriasis vulgaris.
ControlsThe 218 controls were healthy blood donors living in the Los Angeles metropolitan area.
ComparisonsHLA antigen frequencies in patients and controls were compared using Fisher's exact test (Armitage, 1971) and the relative risk values were calculated by the formula of Woolf (1955).To determine whether any DR antigens are associated with clinical subgroups of psoriasis, the patients were subdivided according to:(a) the age at onset (less than 36 years vs greater than 35 years); (b) presence or absence of arthritis; (c) presence or absence of a family history of psoriasis.
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