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One-electron reductive intramolecular cyclization of enones with ketones or aldehydes mediated by samarium diiodide and electrolysis to afford cis-trimethyl- hydrindanolones. The reactions gave selectivities ranging from 1:1 to 100:0 depending on the conditions.

Clinical research plays a fundamental role in establishing new treatments. Clinical research coordinators are considered essential in clinical research, and medical professionals such as pharmacists often take on this role. Pharmacy students can be considered future candidates for this task. We used questionnaires to survey the knowledge of and attitudes toward registration trials and clinical research of pharmacy students at Tokushima University Hospital. All pharmacy students (103) to whom questionnaires were sent responded. Almost all respondents were aware of registration trials and clinical research. More than 90% were aware of the existence of clinical research coordinators, and about half (48.6%) understood their role. In clinical research terminology, most respondents were aware of informed consent and related issues, but fewer than 20% were aware of more practical things. In total, 29.1% and 40.8% of the respondents were willing to carry out and coordinate research. These findings suggest that pharmacy students have basic knowledge of clinical research and that many students are willing to carry out and coordinate clinical research. More practical exposure to clinical research may help to strengthen their future contribution. Further studies may help to determine how to provide education on registration trials and clinical research to pharmacy students.

der I/II-CP fiillt bei konstantem t mit steigendem [II] ab; fe/fT yon Poly-II steigt mitt stark an, w~ihrend bei Poly-I ein schwa&er Abfall vorliegt, fe/fT yon Poly-IV fiillt sehr stark mit wachsendem tab, bei Poly-III ist fe/fT t-unabh~ingig. Die fe/f-Werte der CP liegen zwischen denen der Homopolymeren, falls t wesentlich gr/5-i~er als die Glastemperatur ist. O. Fuchs (Hofheim)Oguni, N., S. Watanabe u. H. Tani (Dep. of Polymer Sci., Fae. of Sci., Univ., Osaka). 220-MHz-NMR-Untersuchungen an Poly(propylenoxid-~-d). (Polymer J. 4, 664-667, 1973.) Propylenoxyd-u-d wurde entweder in Toluol (I) bei 30 °C mit Zn(CeHs)e + HeO 1:0,7 (daraus Polymeres II) oder in I bei 0 ° mit Al (C2Hs)8 -1-HeO 1:1 (= Polymeres III) oder in Substanz bei 70 ° mit KOt-I (= Polymeres IV) polymerisiert. II wurde durcah L~Ssen in Aceton und Abktihlen der L6sung auf 0 ° in einen kristallinen (= IIa) und einen amorphen Anteil (= IIb) zerlegt. Von IIa, IIb, III und IV wurden in CDCla und in C6D6 die NMR-Spektren aufgenommen. Die relativen Intensitiiten der isotaktischen und syndiotaktischen Diaden betragen 98 und 2 °/0 in IIa, 57 und 43 (IIb), 73 und 27 (III), je 50 (IV). In III liegen 37°/0 Kopf-Kopf-Verkniipfungen vor. 0, Fuchs (Hofheim) Mitsuda, Y., ]. L. Schrag u. ]. D. Ferry (Dep. of Chem. and Rheology Res. Center, Univ., Madison). Visko-

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