Unfit patients with ultracentral tumors who were treated using this scheme had a high local control and a median survival of 15.9 months. Despite manifestation of rates of a fatal lung bleeding comparable to those seen with conventional radiotherapy for endobronchial tumors, the overall rate of G5 toxicity is of potential concern. Additional work is needed to identify tumor and treatment factors related to hemorrhage.
Introduction: Previous study demonstrated that the baseline lung immune prognostic index (LIPI) was a potential biomarker which can identify advanced non-small cell lung cancer (NSCLC) patients who will benefit from treatment with immune checkpoint inhibitor (ICI). However, a recent study found that the LIPI might be an important prognostic biomarker irrespective of treatment modality for patients with metastatic NSCLC. It remains unclear whether LIPI is associated with long-term outcomes in unresected stage III NSCLC. Methods: Patients with LA-NSCLC treated with definitive radiotherapy (RT) between 2000 to 2017 were retrospectively reviewed. The pretreatment derived neutrophils/ (leukocytes minus neutrophils) ratio (dNLR) and lactate dehydrogenase (LDH) made up the LIPI and divided it into two groups (good, 0 score; poor, 1 to 2 scores). Overall survival (OS), progressionfree survival (PFS), locoregional relapse-free survival (LRRFS), and distant metastasis-free survival (DMFS) were calculated from the date of diagnosis. Kaplan-Meier method and Cox hazards regression analysis were used to explore associations between the LIPI and LA-NSCLC prognosis. Propensity score matching (PSM) was conducted to balance the confounding variables. Results: A total of 1079 patients were eligible for analysis. Patients with a poor pretreatment LIPI had significantly inferior OS, PFS, LRRFS, and DMFS than those with a good LIPI (median OS, 19.0 vs 25.0 months, Log-rank P < 0.001; median PFS, 10.0 vs 13.0 months, Log-rank P ¼ 0.001; median LRRFS, 13.0 vs 18.0 months, Log-rank P < 0.001; median DMFS, 15.0 vs 17.0 months, Logrank P ¼ 0.002). According to multivariate analysis, it was also found that the LIPI was an independent prognostic marker for OS (P ¼ 0.026,
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