The ESA mission Rosetta, launched on March 2nd, 2004, carries an instrument suite to the comet 67P/Churyumov-Gerasimenko. The COmetary Secondary Ion Mass Anaylzer -COSIMA -is one of three cometary dust analyzing instruments onboard Rosetta. COSIMA is based on the analytic measurement method of secondary ion mass spectrometry (SIMS). The experiment's goal is in-situ analysis of the elemental composition (and isotopic composition of key elements) of cometary grains. The chemical characterization will include the main organic components, present homologous and functional groups, as well as the mineralogical and petrographical classification of the inorganic phases. All this analysis is closely related to the chemistry and history of the early solar system. COSIMA covers a mass range from 1 to 3500 amu with a mass resolution m/ m @ 50% of 2000 at mass 100 amu. Cometary dust is collected on special, metal covered, targets, which are handled by a target manipulation unit. Once exposed to the cometary dust environment, the collected dust grains are located on the target by a microscopic camera. A pulsed primary indium ion beam (among other entities) releases secondary ions from the dust grains. These ions, either positive or negative, are selected and accelerated by electrical fields and travel a well-defined distance through a drift tube and an ion reflector. A microsphere plate with dedicated amplifier is used to detect the ions. The arrival times of the ions are digitized, and the mass spectra of the secondary ions are calculated from these time-of-flight spectra. Through the instrument commissioning, COSIMA took the very first SIMS spectra of the targets in space. COSIMA will be the first instrument applying the SIMS technique in-situ to cometary grain analysis as Rosetta approaches the comet 67P/Churyumov-Gerasimenko, after a long journey of 10 years, in 2014.

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Although blood flows in a pulsatile fashion, little consideration has been given in past studies to its instantaneous resistance to motion when onset and cessation of flow occur abruptly. Hemorheological studies have documented three kinds of blood flow properties. 1) Shear thinning is a fall in viscolity as shear rate rises. 2) Viscoelasticity is a transient shear stress variation due to elastic deformation of erythrocytes. Dilatancy is a viscoelasticity-modifying property attributed to high shear rate erythrocyte rigidity; viscoelasticity is prominent only at low shear rate. 3) Thixotropy is an initial extra flow resistance linked to developing orientation and disaggregation of erythrocytes. Thixotropy returns fully to blood over a period longer than 1 min. Measurements utilizing a fast response Couette viscometer have revealed an extra 10% transient flow resistance after a flow cessation shorter than that between heart beats. The rapidly recovered transient flow resistance has a temporal pattern similar to thixotropy. Its peak and duration are directly related to total shear strain (shear rate x time) over the 8-30 s-1 shear rate range studied. Transient behavior was essentially identical in analyses carried out using three different viscometer gaps. Numerical simulation to test the effect of the newly observed transient behavior on sudden onset tube flow shows that the developing pattern of pulsatile arterial flow can be affected by its presence.

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