10In the present work, internal standardization based on species-unspecific isotope dilution 11 analysis technique is proposed in order to overcome the matrix effects and signal drift originated in 12 the speciation of As in urine by HPLC-ICP-MS. To this end, 72 Ge has been selected as a pseudo-13 isotope of As. The resulting mass flow chromatogram of the element allows the calculation of the 14 corrected overall species concentrations without requiring any methodological calibration, 15providing high-throughput sample processing. The validation was carried out by analyzing a blank 16 human urine fortified at three concentration levels and an unspiked human urine sample containing 17 different species of arsenic. In all cases, recoveries ranging from 90 to 115% and RSD below 10% 18 were attained with this approach. Furthermore, the proposed method provided results in excellent 19 agreement with those obtained using standard additions and internal standard calibration, allowing a 20 fast way to assess human exposure to arsenic species. 21
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.