We studied activity and dynamics of apoptosis of peripheral blood lymphocytes in patients with myocardial infarction and analyzed the relationship of these processes with expression of heat shock proteins with a molecular weight of 70 kDa playing an essential role in preventing cell death. Thus, we first demonstrated activation of apoptosis in peripheral blood cells of patients with myocardial infarction compared to the control (healthy individuals) and revealed the expected negative correlation between the expression of heat shock proteins with a molecular weight of 70 kDa by lymphocytes and intensity of their death. The observed dynamics of mononuclear cell apoptosis in the peripheral blood of patients with myocardial infarction can reflect activity of programmed cardiomyocyte death in the focus of ischemic injury.
997.In the process of use many parts are subjected to the impact action of abrasive particles contained in a flow (jet) of gas or liquid and ones present on the contacting surfaces in the form of an abrasive layer. Despite the large number of publications devoted to problems of wear of parts, no universal criterion has been developed for evaluating the wear resistance of materials operating under various wear conditions. The present work concerns hydraulic and impact abrasion of various steels and alloys of nonferrous metals. In establishing the dependence of the wear resistance of the studied materials on their proper'des the authors take into account for the first time the rigidity of the stress state of the worn surfaces, which allows them to explain the special features of the behavior of the materials when subjected to various kinds of abrasion wear.In choosing the material for a part used under conditions of wear it is very important to determine what structure and properties are optimum for providing their maximum endurance [1,2]. The problem of optimizing the structure and properties to obtain a combination of high wear resistance and the requisite structural strength for the part, i.e., an optimum ratio of the surface and bulk strength of the part under specific operating conditions, is no less important. This paper presents results of a study of wear in various materials with the aim of developing a universal criterion of wear resistance.Tests of cylindrical specimens for hydraulic abrasion wear were conducted in a trough installation [2,3] with movement of the specimens at a linear sped v = 3.1 m/sec in a working medium consisting of water and quartz sand with particles 0.3 -1.6 turn in size in a 3-to-7 proportion (volume fractions).In tests for impact abrasion wear cylindrical specimens 10 mm in diameter collided periodically, by impact of their end faces, with an anvil covered with a 14A32NM abrasive cloth. At the moment of collision the abrasive cloth was immobile, i.e., the impact was direct. The impact energy in the tests was 0.5 J.The mechanical properties and the relative wear resistance (K, w )HA and (K~x u )la of the materials tested for hydraulic (HA) and impact (IA) abrasion wear are presented in Table I. In both series of tests the standard specimens were made of carbon steel 25L in a cast state.St. Petersburg State University of Water Communications, St. Petersburg, Russia.The dependence of (K6u)m,, of the materials on their hardness HI'is presented in Fig. la. The points in Fig. 12 can be grouped around four cu~'es corresponding to a power dependence (K,~I.)H A = const I HV",where cons h is a constant and t7 is an exponent varying from 3 to 1.5. In the lower part of Fig. l a we present dependences of the coefficient of rigidity of the stress state P of the studied materials on their hardness for angles of collision ct between the abrasive particles and the worn surface equal to 90 ~ , 45 ~ , and _~ 0 ~ At c~ z 0 ~ the collision betv,,een the particles and the surface of the specimen occur...
Loading of neutrophils with immune complexes changed their functional activity and intracellular pH. These changes depended on the size of immune complexes. UV irradiation of neutrophils loaded with immune complexes led to a molecular weight-dependent decrease in intracellular pH. After irradiation the chemiluminescence response to latex increased only in neutrophils loaded with non-phagocytized immune complexes with low (less than 10 units IgG) and high molecular weights (more than 25 units IgG).
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