extend to a greater number of patients and include other drugs with adjustment to renal function. In order to validate the estimated renal function and understand which formula is closest to reality, it would be important to determine the measured GFR. Controversy remains as to whether adoption of eGFR for drug dosing is appropriate given that dosing recommendations for many available drugs are based on CG estimates of kidney function. Using the same kidney function estimate for management of kidney disease, drug development and dosing would harmonise all clinical areas.
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