Among the 12 participants, the 6 with the most abnormal obesity-related traits were slightly older (13 vs. 11 years) but had similar BMI (Z-score 2.3 vs. 2.2) and % body fat (39% vs. 38%). Among the candidate regions, triglycerides were associated with differential methylation at cg20809737, intronic to the fatty acid oxidation enzyme carnitine palmitoyltransferase 1A, CPT1A (p¼0.006). CONCLUSION: We demonstrate an association between differential methylation of CPT1A and triglycerides in children, supporting similar findings from adult studies. Epigenetic mechanisms may confer increased susceptibility to developing obesity-related dyslipidemia via alterations in DNA methylation.
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