Rats with standardized burns and skin excision wounds were treated i.p. with human fibronectin or swine skin gelatin. Controls received bovine albumin, solvent, or no treatment. Wound healing was assessed by planimetry, additionally plasma fibronectin was determined. Solvent or albumin did not influence the healing process, neither did fibronectin. However, when opsonizing fibronectin was additionally consumed by application of gelatin, a significant retardation of wound healing was observed. The results support the opinion that fibronectin is of essential importance for posttraumatic opsonization of gelatin-like material originating from the damaged tissue.
In the operative treatment of appendicitis the so called negative appendectomy is an important issue because of its increased morbidity. From the hypothesis that the intestinal diamine oxidase activity is a suitable marker of mucosal integrity, the distribution pattern of the enzyme in appendices histologically classified as inflamed or not inflamed was studied. Histologically apparent inflammation of the appendix was connected with a significant reduction of diamine oxidase activity. The determination of this enzymic activity may be a simple and sensitive test for mucosal inflammation of the appendix even at a very early state. This could reduce the rate of negative appendectomies and influence thereby risk-cost-benefit calculations.
We examined 1001 patients with the provisional diagnosis of "acute abdominal pain".Surgical conditions accounted for 67.7 %. Of all patients with acute appendicitis, 73 % were under 30 years of age. Most (83.5 %) patients with acute cholangitis and cholecystitis were in the 4th-5th decades of life. Of those, 71.1% were women. Of all acute complications associated with a gastric or duodenal ulcer, two-thirds were detected in 20-to 50-years-old patients, of whom 75 % were men. Among cases of acute gynaecological disease with abdominal pain, 82.3 % were in 10-to 40-year-old women. Urological patients were mainly (74.4 %) 20-50 years old. Of those, 69 % were men. These data may influence the clinical decisions involved in establishing a definite diagnosis.
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