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Skin lesions with histopathology similar to that seen in lesions in man have been produced in calves by the experimental inoculation of cultures of Myco. ulcerans. Sensitization of infected calves to mammalian tuberculin as well as to ulceranin has been demonstrated.It is considered unlikely that cattle are a reservoir of infection for man.The expenses of this investigation were met by a research grant from the Board of Management, Alfred Hospital.We are indebted to Dr A. V. Jackson, Director of Pathology, Alfred Hospital, for the reports on histopathology.

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