Pyridazine derivatives R 0500Synthesis of Novel Allylthio Heterocyclo(or aryl)alkylaminopyridazines and Their Anticancer Activity Against SK-Hep-1 Cells. -The title compounds (III) show antiproliferative activities against SK-Hep-1 human liver cancer cells in MTT assays. Thus, they are promising candidates for the chemotherapy of hepatocellular carcinomas. Compounds (IIIc) and (IIIi) exhibit higher potencies for inhibiting the growth of hepatocellular carcinoma cells than K6. -(LEE, M.-S.; KIM, E.-S.; MOON, A.; PARK*, M.-S.; Bull. Korean Chem. Soc. 30 (2009) 1, 83-91; Coll. Pharm., Duksung Women's Univ., Seoul 132-714, S. Korea; Eng.) -H. Toeppel 28-141
Synthesis of 3-Aminohydantoinyl-1,2-benzothiazine Derivatives. -The synthesis of several new 3-aminohydantoinylbenzothiazine derivatives (VII) (9 examples), which exhibit good analgesic and anti-inflammatory activities, based on the condensation of related benzothiazines (VI) with 3-aminohydantoins (IV) derived from L-amino acids (I) is accomplished. -(PARK, M.-S.; CHANG, E.-S.; LEE, M.-S.; KWON*, S.-K.; Bull. Korean Chem.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.