Patients with HNC are a diverse group, with complex educational and support needs. Patients appear to be given information regarding survivorship topics such as psychological well-being, patient support groups, and psychosexual health less frequently than information concerning disease and treatment. Verbal communication needs to be reinforced by accessible, well-constructed, written and multimedia resources appropriate to the patient's educational level. Cancer 2017;123:1949-1957. © 2017 American Cancer Society.

No abstract

SLNB for early OCSCC is technically feasible in an Australian setting. It has a high NPV and can potentially identify at-risk lymphatic basins outside the traditional selective neck dissection levels even in well-lateralized lesions.

For 20 cases, deep-learning delineation outperformed 4 of the 8 radiation oncologists, with mean DSC of 0.766 against 0.691, 0.699, 0.704 and 0.719 (all P < 0.05); while performed comparably to another 4 oncologists. With the assistance of deep-learning delineation, increased delineation accuracy was observed in 5 oncologists (mean DSC increased from 0.731 to 0.779; all P < 0.05) and stable DSC in 3 oncologists. Furthermore, decreased multi-observer DSC was observed (0.774 AE 0.0773 vs. 0.702 AE 0.114; P < 0.001). Average time spent decreased from 30.2 min on manual delineation to 18.3 min in editing deep-learning delineation (P < 0.001), saving 39.2% of the time. Conclusion: In GTV p delineation for NPC, deep-learning delineation achieved satisfactory agreement in comparison with expert-panel delineation, and outperformed 4 of 8 qualified radiation oncologists significantly. Assistance of deep-learning delineation consistently improved both the accuracy and efficiency.

different from that of a ranula, this raises the question of whether we should be more comprehensive in our preoperative assessment.Some have argued that a cystic mass of the head and neck warranted routine radiological assessments, 1 and needed computed tomography (CT) or magnetic resonance imaging if any atypical features were found. 2 Some advocated CT, even as early as 1987, 3 for the evaluation of all clinical cystic lesions. Others further recommended fine needle aspiration prior to surgical excision. 4 In the absence of a randomized trial, the best treatment protocol is yet to be developed. When solely discussing the pickup rate of an epidermoid cyst from a clinical lesion, the number needed to treat (NNT) is 15. Our opinion is that the NNT might be justifiable for routine noninvasive investigations, for example, ultrasound References 1. Turetschek K, Hospodka H, Steiner E. Epidermoid cyst of the floor of the mouth: diagnostic imaging by sonography, computed tomography and magnetic resonance imaging. Br. J. Radiol. 1995; 68: 205-7. 2. Woo EK, Connor SEJ. Computed tomography and magnetic resonance imaging appearances of cystic lesions in the suprahyoid neck: a pictorial review. Dentomaxillofac. Radiol. 2007; 36: 451-8. 3. Coit WE, Harnsberger HR, Osborn AG, Smoker WRK, Stevens MH, Lufkin RB. Ranulas and their mimics: CT evaluation. Radiology 1987; 163: 211-6. 4. Walstad WR, Solomon JM, Schow SR, Ochs MW. Midline cystic lesion of the floor of the mouth.

Background: Sentinel lymph node biopsy (SLNB) has been pivotal for pathological assessment of nodal status in cutaneous melanoma (CM) and oral cavity squamous cell carcinoma (OCSCC) thus crucial for staging. An ideal agent for lymphatic mapping should have a standardized preparation, appropriate accumulation in first-echelon nodes and no side effects. Tilmanocept, a CD206-receptor targeted novel radiotracer fulfils these properties. This study investigated Tilmanocept for lymphoscintigraphy and intraoperative identification of sentinel lymph nodes (SLN) in CM and OCSCC. Methods: This prospective cross sectional study examined patients who presented to Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney. Patients had biopsy proven tumours with clinically and radiologically negative regional lymph nodes. Tilmanocept guided lymphoscintigraphy was followed by intraoperative SLNs identification via handheld gamma probe. Primary endpoints were detection and retrieval rate of SLNs while secondary endpoints included pathological status of SLNs. Results: Thirty-five patients were included (26 with CM and 9 with OCSCC) with the most common primary tumour site for CM on the extremities (33.3%). Lymphoscintigraphy with Tilmanocept identified at least 1 SLN (sensitivity 100%) in all patients. SLNs were retrieved in all of patients intraoperatively (100% retrieval rate) with positive nodes found in 20% of patients. Tilmanocept also demonstrated 100% tissue specificity, with lymph nodal tissue confirmed histologically, with no false positives. Conclusion: Tilmanocept is a reliable radiotracer for assessing the nodal status in patients with CM and OCSCC. Our group is the first to evaluate the use of Tilmanocept in the Australian setting, adding to the limited studies worldwide.

Ameloblastic carcinoma is a rare type of ameloblastoma that has received little mention in the literature. While a number of cases have been published over many years, no institution has been able to produce a substantial case series. Ameloblastic carcinoma originates in the embryonic tooth components. It is believed to be an aggressive tumor that can metastasize; once metastasis occurs, the prognosis tends to be poor. Ameloblastic carcinoma is primarily a surgical condition that is best treated with resection; there has been little indication that other modalities are helpful. We present the case of a 40-year-old woman who was found to have a mandibular lesion by a dentist. After surgical resection, the tumor was found to be an ameloblastic carcinoma. The patient recovered without complication, and she was recurrence-free 18 months postoperatively. We also briefly review the available literature on the natural history of and management options for this rare tumor.

No abstract