Capital structure relationship with corporate performance as an unresolved issue became more complicated after the global crisis. This is because of liquidity problems that ensued and firms were looking for strategies of cost reduction and profit increment with a view to enhance performance. This paper examines the impact of capital structure choices (Equity or Debt) on performance of selected firms in US in the pre, during and post crisis periods (2003-2006), 2007-2008 and 2009-2012 respectively) with a view to determine whether or not the relationship between the two variables is period related. Statistically, multiple Regression Model was used to estimate the relationship as performance was measured using Return on Equity (ROE), Return on Assets (ROA), Price per Share (P/E Ratio), Earnings Per Share (EPS) and Tobin's Q (TQ) while capital structure is proxy by Debt to Equity ratio and Firm size was introduced as control variable using 200 selected listed companies from 10 sectors in the US Stock Exchange. The study finds mixed results such that impact of capital structure on corporate performance depends on the type of performance used and is period related. For instance, higher levels of gearing have negative significant relationship with ROA (-0.362) and (-1.13) before and after the crisis respectively or (-0391) using the pooled data, but a positive significant relationship exist between DE and ROA in the post crisis period other variables shows insignificant relationship. More precisely, a percentage increase in the level of debt brings 46% changes in ROA. Generally capital structure is not a major determinant of corporate performance as it has insignificant impact (15%) on corporate performance of US companies. The study recommends that companies should pay little attention to capital structure but look outwards to human capital development/ managerial efficiency in asset utilization for performance enhancement.