Abstract-This paper describes the world's largest gait database-the "OU-ISIR Gait Database, Large Population Dataset"-and its application to a statistically reliable performance evaluation of vision-based gait recognition. Whereas existing gait databases include at most 185 subjects, we construct a larger gait database that includes 4007 subjects (2135 males and 1872 females) with ages ranging from 1 to 94 years. The dataset allows us to determine statistically significant performance differences between currently proposed gait features. In addition, the dependences of gait-recognition performance on gender and age group are investigated and the results provide several novel insights, such as the gradual change in recognition performance with human growth.
The Japanese herb, Ashitaba (Angelica keiskei Koidzumi), contains two prenylated chalcones, 4-hydroxyderricin and xanthoangelol, which are considered to be the major active compounds of Ashitaba. However, their effects on inflammatory responses are poorly understood. In the present study, we investigated the effects and underlying molecular mechanisms of 4-hydroxyderricin and xanthoangelol on lipopolysaccharide (LPS)-induced inflammatory responses in RAW264 mouse macrophages. LPS-mediated production of nitric oxide (NO) was markedly reduced by 4-hydroxyderricin (10 μM) and xanthoangelol (5 μM) compared with their parent compound, chalcone (25 μM). They also inhibited LPS-induced secretion of tumor necrosis factor-alpha (TNF-α) and expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). Although chalcone decreased the DNA-binding activity of both activator protein-1 (AP-1) and nuclear factor-kappa B (NF-κB), 4-hydroxyderricin and xanthoangelol suppressed only AP-1 and had no effect on NF-κB. On the other hand, all of the tested chalcones reduced the phosphorylation (at serine 536) level of the p65 subunit of NF-κB. 4-Hydroxyderricin and xanthoangelol may be promising for the prevention of inflammatory diseases.
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