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Mice depleted of ␥␦ T cells by in vivo administration of anti-TCR␥␦ monoclonal antibodies showed susceptibility against an intravaginal infection with herpes simplex virus type 2 (HSV-2). The systemic Th1 response was impaired in the ␥␦ T-cell-depleted mice. Mice deficient in the V␦1 T subset were susceptible to an intravaginal infection with HSV-2. Intraepithelial ␥␦ T cells bearing V␦1 may help protect against intravaginal infection with HSV-2 through promoting the systemic Th1 response.

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