Background Digital Chest X-ray (dCXR) computer-aided detection (CAD) technology uses lung shape and texture analysis to determine the probability of TB. However, many patients with previously treated TB have sequelae, which also distort lung shape and texture. We evaluated the diagnostic performance of two CAD systems for triage of active TB in patients with previously treated TB. Methods We conducted a retrospective analysis of data from a cross-sectional active TB case finding study. Participants ≥15 years, with ≥1 current TB symptom, and with complete data on history of previous TB, dCXR, and TB microbiological reference (Xpert MTB/RIF) were included. dCXRs were evaluated using CAD4TB (v.7.0) and qXR (v.3.0). We determined the diagnostic accuracy of both systems, overall and stratified by history of TB, using a single threshold for each system that achieved 90% sensitivity and maximized specificity in the overall population. Results Of 1,884 participants, 452 (24.0%) had a history of previous TB. The prevalence of microbiologically confirmed TB among those with and without history of previous TB was 12.4% and 16.9% respectively. Using CAD4TB, the sensitivity and specificity was 89.3% (95%CI:78.1-96.0) and 24.0% (95%CI19.9-28.5) and 90.5% (95%CI:86.1-93.3) and 60.3% (95%CI:57.4-63.0) among those with and without previous TB, respectively. Using qXR, the sensitivity and specificity was 94.6% (95%CI:85.1-98.9) and 22.2% (95%CI:18.2-26.6) and 89.7% (95%CI:85.1-93.2) and 61.8% (95%CI:58.9-64.5) among those with and without previous TB, respectively. Conclusion The performance of CAD systems as a TB triage tool is decreased among persons previously treated for TB.
Background Persistent respiratory symptoms and radiographic abnormalities are common among individuals previously treated for tuberculosis (TB) and may contribute to misdiagnosis and incorrect treatment when they seek care. We sought to determine if clinical and radiographic characteristics differed among previously treated, presumptive TB patients according to their current TB disease status. Methods Adults (>18 years of age) seeking care at a public health facility in Lusaka, Zambia were systematically evaluated for active TB using symptom screening and chest X-ray. All patients with presumptive TB submitted a sputum sample for microbiological TB testing. Patients who reported a prior history of TB treatment were included in the present analysis. ‘Confirmed TB’ was defined by the detection of TB using Xpert Ultra and/or liquid culture, while ‘possible TB’ was defined by the receipt of TB treatment without a positive Xpert Ultra or culture result. We evaluated the positive predictive value (PPV) of clinical symptoms and radiographic features for active TB alone and in combination. Results Of 740 presumptive TB patients, 144 (19%) had been previously treated for active TB. Of these, 19 (13%) patients had confirmed TB, 14 (10%) had possible TB, and 111 (77%) had no pulmonary TB. Overall, 119 (83%) patients had ≥1 current respiratory symptom—this did not differ according to current TB disease classification (95%, 93%, 79%; p = 0.23). Sixty-one patients (56%) had radiographic abnormalities suggestive of active TB and such findings were more common among patients with confirmed or possible TB compared to those without TB (93%, 71%, vs. 47%; p = 0.002). Most patients (n = 91, 83%) had at least one radiographic abnormality—no difference by current TB classification was observed (93%, 100%, 79%; p = 0.08). The PPV of any current respiratory symptom, active TB radiographic finding, or any radiographic abnormality for TB was 13% (95%CI: 7–21%), 21% (95%CI: 12–34) and 14% (95%CI: 9–23), respectively; combining clinical and radiographic characteristics did not significantly improve the PPV for active TB. Conclusions Among presumptive TB patients previously treated for TB, respiratory symptoms and radiographic abnormalities were common and poorly differentiated those with current active TB from those without current active TB. Reliance on clinical and radiographic characteristics alone in this patient population may result in substantial overtreatment and therefore, microbiological investigations should be used to inform TB treatment decisions whenever possible.
Giant cell-rich osteosarcoma of the jaw (JGCRO) is very rare but it is diagnostically important because of its poor prognosis compared to other variants of osteosarcoma. We report a rare case of recurrent JGCRO initially diagnosed as an ossifying fibroma. The clinical presentation, radiologic and histologic features and the intermediate outcome of treatment of the case are highlighted.
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